Literature summary for 1.20.4.2 extracted from

Marnell, L.L.; Garcia-Vargas, G.G.; Chowdhury, U.K.; Zakharyan, R.A.; Walsh, B.; Avram, M.D.; Kopplin, M.J.; Cebrian, M.E.; Silbergeld, E.K.; Aposhian, H.V.
Polymorphisms in the human monomethylarsonic acid (MMA V) reductase/hGSTO1 gene and changes in urinary arsenic profiles (2003), Chem. Res. Toxicol., 16, 1507-1513.

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Protein Variants

Protein Variants	Comment	Organism
additional information	naturally occurring mutations S86C, A140D, E155del, A236V, and E208K significantly decrease enzyme activity	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
methylarsonate + glutathione	Homo sapiens	involved in biotransformation of arsenate	methylarsonite + glutathione disulfide	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P78417	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
methylarsonate + glutathione	-	Homo sapiens	methylarsonite + glutathione disulfide	-	?
methylarsonate + glutathione	involved in biotransformation of arsenate	Homo sapiens	methylarsonite + glutathione disulfide	-	?

Synonyms

Synonyms	Comment	Organism
monomethylarsonic acid (MMA V) reductase/hGSTO1	-	Homo sapiens

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Release 2023.1 (January 2023)