Literature summary for 1.2.7.4 extracted from

Lindahl, P.A.
Implications of a carboxylate-bound C-cluster structure of carbon monoxide dehydrogenase (2008), Angew. Chem., 47, 4054-4056.

Search for more literature for 1.2.7.4

Inhibitors

Inhibitors	Comment	Organism	Structure
S2-	partial inhibitor	Carboxydothermus hydrogenoformans
S2-	partial inhibitor	Neomoorella thermoacetica
S2-	partial inhibitor	Rhodospirillum rubrum

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Fe2+	contains a NiFe center, called C-cluster	Carboxydothermus hydrogenoformans
Fe2+	contains a NiFe center, called C-cluster	Neomoorella thermoacetica
Fe2+	contains a NiFe center, called C-cluster	Rhodospirillum rubrum
Ni2+	contains a NiFe center, called C-cluster	Carboxydothermus hydrogenoformans
Ni2+	contains a NiFe center, called C-cluster	Neomoorella thermoacetica
Ni2+	contains a NiFe center, called C-cluster	Rhodospirillum rubrum

Organism

Organism	UniProt	Comment	Textmining
Carboxydothermus hydrogenoformans	-	-	-
Neomoorella thermoacetica	-	-	-
Rhodospirillum rubrum	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
CO + H2O + acceptor	-	Carboxydothermus hydrogenoformans	CO2 + reduced acceptor	-	r
CO + H2O + acceptor	-	Rhodospirillum rubrum	CO2 + reduced acceptor	-	r
CO + H2O + acceptor	-	Neomoorella thermoacetica	CO2 + reduced acceptor	-	r

Subunits

Subunits	Comment	Organism
homodimer	-	Carboxydothermus hydrogenoformans
homodimer	-	Rhodospirillum rubrum
homodimer	-	Neomoorella thermoacetica

Synonyms

Synonyms	Comment	Organism
ACS/CODH	bifunctional enzyme with ACS alpha subunits and CODH beta subunits	Neomoorella thermoacetica
CODH	-	Carboxydothermus hydrogenoformans
CODH	-	Rhodospirillum rubrum

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Release 2026.1 (March 2026)