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Literature summary for 1.2.7.1 extracted from

  • Warren, C.A.; van Opstal, E.; Ballard, T.E.; Kennedy, A.; Wang, X.; Riggins, M.; Olekhnovich, I.; Warthan, M.; Kolling, G.L.; Guerrant, R.L.; Macdonald, T.L.; Hoffman, P.S.
    Amixicile, a novel inhibitor of pyruvate ferredoxin oxidoreductase, shows efficacy against Clostridium difficile in a mouse infection model (2012), Antimicrob. Agents Chemother., 56, 4103-4111 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.2.7.1

Inhibitors

Inhibitors Comment Organism Structure
nitazoxanide 52% inhibition at 0.040 mM, 25°C, pH 7.4 Clostridioides difficile
VPC161183 36% inhibition at 0.040 mM, 25°C, pH 7.4 Clostridioides difficile
VPC161195 56% inhibition at 0.040 mM, 25°C, pH 7.4 Clostridioides difficile
VPC161219 61% inhibition at 0.040 mM, 25°C, pH 7.4 Clostridioides difficile
VPC162096
-
 Clostridioides difficile
VPC162125 71% inhibition at 0.040 mM, 25°C, pH 7.4 Clostridioides difficile
VPC162134 75% inhibition at 0.040 mM, 25°C, pH 7.4 Clostridioides difficile
VPC16a1011 34% inhibition at 0.040 mM, 25°C, pH 7.4 Clostridioides difficile
VPC16b1094 66% inhibition at 0.040 mM, 25°C, pH 7.4 Clostridioides difficile
VPC16b2031 84% inhibition at 0.040 mM, 25°C, pH 7.4 Clostridioides difficile

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pyruvate + CoA + oxidized ferredoxin Clostridioides difficile
-
 acetyl-CoA + CO2 + reduced ferredoxin + H+
-
 ?
pyruvate + CoA + oxidized ferredoxin Clostridioides difficile ATCC 43255
-
 acetyl-CoA + CO2 + reduced ferredoxin + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Clostridioides difficile
-
-
-
Clostridioides difficile ATCC 43255
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyruvate + CoA + oxidized benzyl viologen
-
 Clostridioides difficile acetyl-CoA + CO2 + reduced benzyl viologen + H+
-
 ?
pyruvate + CoA + oxidized benzyl viologen
-
 Clostridioides difficile ATCC 43255 acetyl-CoA + CO2 + reduced benzyl viologen + H+
-
 ?
pyruvate + CoA + oxidized ferredoxin
-
 Clostridioides difficile acetyl-CoA + CO2 + reduced ferredoxin + H+
-
 ?
pyruvate + CoA + oxidized ferredoxin
-
 Clostridioides difficile ATCC 43255 acetyl-CoA + CO2 + reduced ferredoxin + H+
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.008
-
 25°C, pH 7.4 Clostridioides difficile VPC162134
0.024
-
 25°C, pH 7.4 Clostridioides difficile nitazoxanide