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Literature summary for 1.2.4.4 extracted from

  • Knapik-Czajka, M.
    Stimulation of rat liver branched-chain alpha-keto acid dehydrogenase activity by low doses of bezafibrate (2013), Toxicology, 306, 101-107.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
bezafibrate i.e. 2-[4-[2-(4-chlorobenzamido)ethyl]phenoxy]-2-methylpropanoic acid. In rats treated with 5, 10, 20 mg/kg bezafibrate mean enzyme actual activity is 1.9, 2.9, and 4.3fold higher than in the control group, respectively. Enzymatic total activity increases by 1.3 and 1.6fold in rats treated with 10 and 20 mg/kg bezafibrate Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine Rattus norvegicus
-
[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxoisovalerate + NAD+
-
Rattus norvegicus ? + NADH
-
?
3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine
-
Rattus norvegicus [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2
-
?

Synonyms

Synonyms Comment Organism
BCKDH
-
Rattus norvegicus
branched-chain alpha-keto acid dehydrogenase
-
Rattus norvegicus
branched-chain alpha-ketoacid dehydrogenase complex
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus mRNA expression is not upregulated by bezafibrate treatment additional information