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Literature summary for 1.2.4.4 extracted from

  • Parker, P.J.; Randle, P.J.
    Branched chain 2-oxo-acid dehydrogenase complex of rat liver (1978), FEBS Lett., 90, 183-186.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
thiamine diphosphate Km: 0.0012 mM in the reaction with 3-methyl-2-oxobutanoate Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
isopentanoyl-CoA
-
Rattus norvegicus
NADH
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0105
-
DL-3-methyl-2-oxopentanoate
-
Rattus norvegicus
0.013
-
3-methyl-2-oxobutanoate
-
Rattus norvegicus
0.0146
-
4-methyl-2-oxopentanoate
-
Rattus norvegicus
0.0387
-
NAD+ reaction with DL-3-methyl-2-oxopentanoate Rattus norvegicus
0.0395
-
NAD+ reaction with 3-methyl-2-oxobutanoate Rattus norvegicus
0.0423
-
NAD+ reaction with 4-methyl-2-oxopentanoate Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Rattus norvegicus 5739
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
multienzyme complex Rattus norvegicus
partial Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine
-
Rattus norvegicus [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2
-
?
3-methyl-2-oxopentanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine
-
Rattus norvegicus [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine + CO2
-
?
4-methyl-2-oxopentanoate + NAD+ + CoA
-
Rattus norvegicus 3-methylbutanoyl-CoA + CO2 + NADH
-
?

Cofactor

Cofactor Comment Organism Structure
CoA
-
Rattus norvegicus
NAD+
-
Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0082
-
isovaleryl-CoA reaction with 3-methyl-2-oxobutanoate Rattus norvegicus
0.0101
-
isovaleryl-CoA reaction with DL-3-methyl-2-oxopentanoate Rattus norvegicus
0.0136
-
isovaleryl-CoA reaction with 4-methyl-2-oxopentanoate Rattus norvegicus
0.0177
-
NADH reaction with 3-methyl-2-oxobutanoate Rattus norvegicus
0.018
-
NADH reaction with 4-methyl-2-oxopentanoate Rattus norvegicus
0.023
-
NADH reaction with DL-3-methyl-2-oxopentanoate Rattus norvegicus