Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.2.4.4 extracted from

  • Paxton, R.; Scislowski, P.W.D.; Davis, E.J.; Harris, R.A.
    Role of branched-chain 2-oxo acid dehydrogenase and pyruvate dehydrogenase in 2-oxobutyrate metabolism (1986), Biochem. J., 234, 295-303.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
thiamine diphosphate
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0258
-
2-oxobutanoate
-
Rattus norvegicus
0.82
-
pyruvate
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus the intramitochondrial pyruvate dehydrogenase complex and the branched-chain 2-oxo acid dehydrogenase complex are responsible for the oxidative decarboxylation of 2-oxobutanoate, the branched-chain 2-oxo acid dehydrogenase complex is probably the more important complex ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Rattus norvegicus
-
kidney
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
muscle
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine
-
Rattus norvegicus [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(propanoyl)dihydrolipoyllysine + CO2
-
?
3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine
-
Rattus norvegicus [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2
-
?
additional information the intramitochondrial pyruvate dehydrogenase complex and the branched-chain 2-oxo acid dehydrogenase complex are responsible for the oxidative decarboxylation of 2-oxobutanoate, the branched-chain 2-oxo acid dehydrogenase complex is probably the more important complex Rattus norvegicus ?
-
?
pyruvate + NAD+ + CoA
-
Rattus norvegicus acetyl-CoA + CO2 + NADH
-
?

Cofactor

Cofactor Comment Organism Structure
CoA
-
Rattus norvegicus
NAD+
-
Rattus norvegicus