Activating Compound | Comment | Organism | Structure |
---|---|---|---|
thiamine diphosphate | - |
Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-chloroisocaproate | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.01 | - |
3-methyl-2-oxopentanoate | - |
Rattus norvegicus | |
0.011 | - |
4-methyl-2-oxopentanoate | - |
Rattus norvegicus | |
0.011 | - |
3-methyl-2-oxobutanoate | - |
Rattus norvegicus | |
2.2 | - |
pyruvate | - |
Rattus norvegicus | |
2.5 | - |
2-oxoglutarate | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
additional information | - |
MW of the multienzyme complex is 2000000 Da, determined by sucrose density gradient centrifugation | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
multienzyme complex | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
muscle | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-oxoglutarate + NAD+ + CoA | - |
Rattus norvegicus | 3-carboxypropionyl-CoA + NADH + CO2 | - |
? | |
3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine | - |
Rattus norvegicus | [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2 | - |
? | |
3-methyl-2-oxopentanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine | - |
Rattus norvegicus | [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine + CO2 | - |
? | |
4-methyl-2-oxopentanoate + NAD+ + CoA | - |
Rattus norvegicus | 3-methylbutanoyl-CoA + CO2 + NADH | - |
? | |
pyruvate + NAD+ + CoA | - |
Rattus norvegicus | acetyl-CoA + CO2 + NADH | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
CoA | - |
Rattus norvegicus | |
NAD+ | - |
Rattus norvegicus |