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Literature summary for 1.2.4.4 extracted from

  • Ono, K.; Hakozaki, M.; Kimura, A.; Kochi, H.
    Purification, resolution, and reconstitution of rat liver branched-chain alpha-keto acid dehydrogenase complex (1987), J. Biochem., 101, 19-27.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
thiamine diphosphate
-
Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
2-chloroisocaproate
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.01
-
3-methyl-2-oxopentanoate
-
Rattus norvegicus
0.011
-
4-methyl-2-oxopentanoate
-
Rattus norvegicus
0.011
-
3-methyl-2-oxobutanoate
-
Rattus norvegicus
2.2
-
pyruvate
-
Rattus norvegicus
2.5
-
2-oxoglutarate
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
MW of the multienzyme complex is 2000000 Da, determined by sucrose density gradient centrifugation Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
multienzyme complex Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-
muscle
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxoglutarate + NAD+ + CoA
-
Rattus norvegicus 3-carboxypropionyl-CoA + NADH + CO2
-
?
3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine
-
Rattus norvegicus [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2
-
?
3-methyl-2-oxopentanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine
-
Rattus norvegicus [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine + CO2
-
?
4-methyl-2-oxopentanoate + NAD+ + CoA
-
Rattus norvegicus 3-methylbutanoyl-CoA + CO2 + NADH
-
?
pyruvate + NAD+ + CoA
-
Rattus norvegicus acetyl-CoA + CO2 + NADH
-
?

Cofactor

Cofactor Comment Organism Structure
CoA
-
Rattus norvegicus
NAD+
-
Rattus norvegicus