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Literature summary for 1.2.4.4 extracted from

  • Pettit, F.H.; Reed, L.J.
    Branched-chain alpha-keto acid dehydrogenase complex from bovine kidney (1988), Methods Enzymol., 166, 309-312.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
thiamine diphosphate
-
Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
isobutanoyl-CoA 0.2 mM, 48% inhibition Bos taurus
isopentanoyl-CoA 0.2 mM. 56% inhibition Bos taurus
NADH
-
Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.056
-
2-oxobutanoate
-
Bos taurus
1
-
pyruvate
-
Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Bos taurus 5739
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
multienzyme complex Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
8.8
-
multienzyme complex Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 50% of the activity with 3-methyl-2-oxobutanoate Bos taurus [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(propanoyl)dihydrolipoyllysine + CO2
-
?
3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine
-
Bos taurus [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2
-
?
3-methyl-2-oxopentanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine
-
Bos taurus [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine + CO2
-
?
4-methyl-2-oxopentanoate + NAD+ + CoA
-
Bos taurus 3-methylbutanoyl-CoA + CO2 + NADH
-
?
pyruvate + NAD+ + CoA 20% of the activity with 3-methyl-2-oxobutanoate Bos taurus acetyl-CoA + CO2 + NADH
-
?

Cofactor

Cofactor Comment Organism Structure
CoA
-
Bos taurus
NAD+
-
Bos taurus