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Literature summary for 1.2.4.4 extracted from

  • Chuang, D.T.
    Assays for E1 and E2 components of the branched-chain keto acid dehydrogenase complex (1988), Methods Enzymol., 166, 146-154.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
thiamine diphosphate
-
Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
4-(3-Thienyl)-2-oxo-3-butenoate
-
Bos taurus
cinnamylpyruvate
-
Bos taurus
Clofibrate
-
Bos taurus
Furfurylidenepyruvate
-
Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0062
-
4-methyl-2-oxopentanoate
-
Bos taurus
0.0106
-
3-methyl-2-oxobutanoate
-
Bos taurus
0.173
-
pyruvate
-
Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
assay method Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine
-
Bos taurus [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2
-
?
4-methyl-2-oxopentanoate + NAD+ + CoA
-
Bos taurus 3-methylbutanoyl-CoA + CO2 + NADH
-
?
pyruvate + NAD+ + CoA
-
Bos taurus acetyl-CoA + CO2 + NADH
-
?

Cofactor

Cofactor Comment Organism Structure
CoA
-
Bos taurus
NAD+
-
Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0005
-
Furfurylidenepyruvate
-
Bos taurus
0.15
-
4-(3-Thienyl)-2-oxo-3-butenoate
-
Bos taurus
0.5
-
cinnamylpyruvate
-
Bos taurus