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Literature summary for 1.2.4.4 extracted from

  • Lau, K.S.; Cooper, A.J.L.; Chuang, D.T.
    Inhibition of the bovine branched-chain 2-oxo acid dehydrogenase complex and its kinase by arylidenepyruvates (1990), Biochim. Biophys. Acta, 1038, 360-366.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
thiamine diphosphate
-
Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
4-(2-Thienyl)-2-oxo-3-butenoate
-
Bos taurus
4-(3-Thienyl)-2-oxo-3-butenoate non-competitive Bos taurus
cinnamylpyruvate non-competitive Bos taurus
Furfurylidenepyruvate competitive Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00067
-
3-methyl-2-oxobutanoate
-
Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine
-
Bos taurus [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2
-
?

Cofactor

Cofactor Comment Organism Structure
CoA
-
Bos taurus
NAD+
-
Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0005
-
Furfurylidenepyruvate
-
Bos taurus
0.15
-
4-(3-Thienyl)-2-oxo-3-butenoate
-
Bos taurus
0.5
-
cinnamylpyruvate
-
Bos taurus