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Literature summary for 1.2.4.1 extracted from

  • Jeng, J.; Huh, T.L.; Song, B.J.
    Production of an enzymatically active E1 component of human pyruvate dehydrogenase complex in Escherichia coli supporting role of E1 beta subunit in E1 activity (1994), Biochem. Biophys. Res. Commun., 203, 225-230 .
    View publication on PubMed

Application

Application Comment Organism
synthesis coexpression of pyruvate dehydrogenase (PDH) E1 alpha and E1 beta subunitsin Escherichia coli leads to fully active E1 protein. The production of E1 alpha alone results in a catalytically inactive protein. The PDH E1 protein produced in Escherichia coli is capable of being phosphorylated by PDH-specific kinase Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
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Organism

Organism UniProt Comment Textmining
Homo sapiens P08559 and P11177 P08559 i.e. pyruvate dehydrogenase E1 component subunit alpha, P11177 i.e. pyruvate dehydrogenase E1 component subunit beta
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Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
PdhA1
-
Homo sapiens
PdhH
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Homo sapiens