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Literature summary for 1.2.4.1 extracted from

  • LeClere, S.; Rampey, R.A.; Bartel, B.
    IAR4, a gene required for auxin conjugate sensitivity in Arabidopsis, encodes a pyruvate dehydrogenase E1alpha homolog (2004), Plant Physiol., 135, 989-999.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.2.4.1

Activating Compound

Activating Compound Comment Organism Structure
additional information effects of several plant hormones and auxin derivatives Arabidopsis thaliana

Cloned(Commentary)

Cloned (Comment) Organism
gene iar4, wild-type sequencing and chromosomal mapping to a 45 kb region 35 cM from the top of chromosome 1 between the markers F3I6.8 and F3I6.17, DNA sequence determination of iar4-1 mutant Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
additional information construction of the iar4-1 mutant, defective in gene iar4 encoding the enzyme E1, by ethylmethane sulfonate, the mutant is less sensitive to a synthetic auxin and low concentrations of an ethylene precursor, but responds to free indole-3-acetic acid and other hormones in a way similar to the wild-type, the Krebs cycle and glycolysis are unaffected Arabidopsis thaliana

Inhibitors

Inhibitors Comment Organism Structure
additional information effects of several plant hormones and auxin derivatives Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Arabidopsis thaliana 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Arabidopsis thaliana conjugates of indole-3-acetic acid with amino acids act as hormones and e.g. inhibit root elongation, the sensitivity of the mutant iar4-1 plant against these conjugates and plant hormones is reduced compared to the wild-type, overview ?
-
 ?
pyruvate + CoA + NAD+ Arabidopsis thaliana
-
 acetyl-CoA + CO2 + NADH
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
 E1alpha component of the pyruvate dehydrogenase multienzyme complex PDH
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information conjugates of indole-3-acetic acid with amino acids act as hormones and e.g. inhibit root elongation, the sensitivity of the mutant iar4-1 plant against these conjugates and plant hormones is reduced compared to the wild-type, overview Arabidopsis thaliana ?
-
 ?
pyruvate + CoA + NAD+
-
 Arabidopsis thaliana acetyl-CoA + CO2 + NADH
-
 ?

Synonyms

Synonyms Comment Organism
E1alpha component of the pyruvate dehydrogenase multienzyme complex PDH Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Arabidopsis thaliana
thiamine diphosphate
-
 Arabidopsis thaliana