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Literature summary for 1.2.4.1 extracted from
- Purification and characterization of the pea chloroplast pyruvate dehydrogenase complex (1985), Plant Physiol., 77, 571-577.
General Stability
| General Stability | Organism |
|---|---|
| very sensitive to freezing and thawing | Pisum sativum |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | enzyme from chloroplast is not inhibited by ATP | Pisum sativum |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1 | - |
Mg2+ | - |
Pisum sativum |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| chloroplast | - |
Pisum sativum | 9507 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | can replace Mg2+ | Pisum sativum | |
| Mg2+ | - |
Pisum sativum | |
| Mn2+ | can replace Mg2+ | Pisum sativum | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pyruvate + lipoamide | Pisum sativum | in overall reaction of pyruvate dehydrogenase complex, pyruvate can be replaced by hydroxypyruvate | S-acetyldihydrolipoamide + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pisum sativum | - |
pea | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| additional information | enzyme from chloroplast is not regulated by phosphorylation/dephosphorylation | Pisum sativum |
| side-chain modification | inactivated by phosphorylation | Pisum sativum |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| pyruvate dehydrogenase complex composed of EC 1.2.4.1, EC 2.3.1.12, EC 1.8.1.4 | Pisum sativum |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| shoot | - |
Pisum sativum | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, 2 weeks, 10-20% loss of activity | Pisum sativum |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pyruvate + lipoamide | in overall reaction of pyruvate dehydrogenase complex, pyruvate can be replaced by hydroxypyruvate | Pisum sativum | S-acetyldihydrolipoamide + CO2 | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
value for pyruvate dehydrogenase complex: 8.0 | Pisum sativum |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
values for pyruvate dehydrogenase complex: pH 7.1-8.8 | Pisum sativum |
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