Literature summary for 1.2.3.6 extracted from

Ramos-Montanez, S.; Tsui, H.C.; Wayne, K.J.; Morris, J.L.; Peters, L.E.; Zhang, F.; Kazmierczak, K.M.; Sham, L.T.; Winkler, M.E.
Polymorphism and regulation of the spxB (pyruvate oxidase) virulence factor gene by a CBS-HotDog domain protein (SpxR) in serotype 2 Streptococcus pneumoniae (2008), Mol. Microbiol., 67, 729-746.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	the trans-acting spxR regulatory gene positively regulates SpxB transcription in response to energy and metabolic state	Streptococcus pneumoniae D39

Application

Application	Comment	Organism
additional information	spxB transcription is regulated by both cis- and trans-acting regulatory elements	Streptococcus pneumoniae D39

Protein Variants

Protein Variants	Comment	Organism
G389D	spxB2 mutant, reduces H2O2 production to approximately that of a DELTAspxB null mutant. SpxB2 mutant shows an opaque colony phenotype and decreased production of H2O2	Streptococcus pneumoniae D39
additional information	cis-acting mutations in spxB decrease H2O2 production. SpxB1 mutant with a 7 bp deletion (Datagaga) of one repeat unit of an adjacent direct repeat centres 136 bp upstream from the translation start codon of SpxB. SpxB1 mutant shows an opaque colony phenotype and decreased production of H2O2. SpxB transcript is greatly reduced (14fold) in the spxB1 mutant compared with parent strain D39. DELTAspxB deletion/insertion mutant, which forms large, opaque colonies on TSA plates similar to those of the spxB2 mutant, produces a minimal basal level of H2O2, and synthesizes capsule	Streptococcus pneumoniae D39
P449L	spxB4 mutant, reduces H2O2 production to approximately that of a DELTAspxB null mutant. SpxB4 mutant shows an opaque colony phenotype and decreased production of H2O2	Streptococcus pneumoniae D39

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	Ala282Thr mutation in strain D39 reduces SpxB activity, probably by reducing FAD binding	Streptococcus pneumoniae D39

Organism

Organism	UniProt	Comment	Textmining
Streptococcus pneumoniae D39	-	serotype 2	-

Synonyms

Synonyms	Comment	Organism
SpxB	-	Streptococcus pneumoniae D39

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Release 2023.1 (January 2023)