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Literature summary for 1.2.1.84 extracted from

  • Li, X.; Zheng, T.; Zheng, X.; Han, N.; Chen, X.; Zhang, D.
    Molecular characterization of two fatty acyl-CoA reductase genes from Phenacoccus solenopsis (Hemiptera Pseudococcidae) (2016), J. Insect Sci., 16, 1-7 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.2.1.84

Application

Application Comment Organism
drug development FAR genes may be potential targets for pest control Phenacoccus solenopsis

Cloned(Commentary)

Cloned (Comment) Organism
gene PsFAR I, DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic tree, quantitative real-time PCR enzyme expression analysis Phenacoccus solenopsis
gene PsFAR II, DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic tree, quantitative real-time PCR enzyme expression analysis Phenacoccus solenopsis

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum membrane the enzyme possesses 2 transmembrane domains, amino acid sites 20-42 and 499-521 Phenacoccus solenopsis 5789
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endoplasmic reticulum membrane the enzyme possesses 2 transmembrane domains, amino acid sites 340-358 and 496-504 Phenacoccus solenopsis 5789
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additional information PsFAR I is a nonsecretory protein since no signal peptide is found Phenacoccus solenopsis
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additional information PsFAR II is a nonsecretory protein since no signal peptide is found Phenacoccus solenopsis
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a long-chain acyl-CoA + 2 NADPH + 2 H+ Phenacoccus solenopsis
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 a long-chain alcohol + 2 NADP+ + coenzyme A
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 ?

Organism

Organism UniProt Comment Textmining
Phenacoccus solenopsis A0A193CHN5
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Phenacoccus solenopsis A0A193CHN6
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Source Tissue

Source Tissue Comment Organism Textmining
nymph gene expression analysis performed at different developmental stages show that the expression of isozyme PsFar I is significantly higher than that of isozyme PsFar II in first and second instar nymphs and in male adults Phenacoccus solenopsis
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a long-chain acyl-CoA + 2 NADPH + 2 H+
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 Phenacoccus solenopsis a long-chain alcohol + 2 NADP+ + coenzyme A
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 ?

Subunits

Subunits Comment Organism
More the isozyme contains a Rossmann folding region and a FAR_C region, two conservative motifs are discovered in Rossmann folding region by sequence alignment including a NADPH combining motif, TGXXGG, and an active site motif, YXXXK Phenacoccus solenopsis

Synonyms

Synonyms Comment Organism
FAR
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 Phenacoccus solenopsis
fatty acyl-CoA reductase
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 Phenacoccus solenopsis
PsFAR I
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 Phenacoccus solenopsis
PsFAR II
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 Phenacoccus solenopsis

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Phenacoccus solenopsis

Expression

Organism Comment Expression
Phenacoccus solenopsis spirotetramat treatment at 125 mg/liter has no effect on the expression of PsFar II additional information
Phenacoccus solenopsis spirotetramat treatment at 125 mg/liter significantly increases the expression of PsFar I in third instar nymphs up

General Information

General Information Comment Organism
metabolism fatty acyl-CoA reductases (FARs) are key enzymes involved in fatty alcohol synthesis Phenacoccus solenopsis
physiological function fatty acyl-CoA reductases (FARs) are key enzymes involved in fatty alcohol synthesis, fatty alcohols are not only the precursors of sex pheromone components but also the precursors of wax-ester in insects. The two FAR genes, PsFAR I and PsFAR II, show different expression patterns during insect development and after pesticide treatment, suggesting that they play different roles in insect development and detoxification against pesticides Phenacoccus solenopsis