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Literature summary for 1.2.1.8 extracted from
- Reaction of the catalytic cysteine of betaine aldehyde dehydrogenase from Pseudomonas aeruginosa with arsenite-BAL and phenylarsine oxide (2009), Chem. Biol. Interact., 178, 64-69.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | PaBADH could be an antimicrobial target | Pseudomonas aeruginosa |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli cells | Pseudomonas aeruginosa |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C353A | mutant, shows similar inactivation kinetics to the wild-type enzyme | Pseudomonas aeruginosa |
| C377A | mutant, shows similar inactivation kinetics to the wild-type enzyme | Pseudomonas aeruginosa |
| C439A | mutant, shows similar inactivation kinetics to the wild-type enzyme | Pseudomonas aeruginosa |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| N-ethylmaleimide | - |
Pseudomonas aeruginosa |  |
| Phenylarsine oxide | PAO | Pseudomonas aeruginosa | |
| sodium meta-arsenite plus 2,3-dimercaptopropanol | arsenite-BAL | Pseudomonas aeruginosa | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| betaine aldehyde + NAD(P)+ + H2O | Pseudomonas aeruginosa | - |
glycine betaine + NAD(P)H + H+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pseudomonas aeruginosa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Pseudomonas aeruginosa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| betaine aldehyde + NAD(P)+ + H2O | - |
Pseudomonas aeruginosa | glycine betaine + NAD(P)H + H+ | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homotetramer | - |
Pseudomonas aeruginosa |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BADH | - |
Pseudomonas aeruginosa |
| betaine aldehyde dehydrogenase | - |
Pseudomonas aeruginosa |
| betaine aldehyde:NAD(P)+ oxidoreductase | - |
Pseudomonas aeruginosa |
| PaBADH | - |
Pseudomonas aeruginosa |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | PaBADH uses NAD+ and NADP+ with similar efficiencies | Pseudomonas aeruginosa | |
| NADP+ | PaBADH uses NAD+ and NADP+ with similar efficiencies | Pseudomonas aeruginosa | |
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