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Literature summary for 1.2.1.70 extracted from

  • Choby, J.E.; Grunenwald, C.M.; Celis, A.I.; Gerdes, S.Y.; DuBois, J.L.; Skaar, E.P.
    Staphylococcus aureus HemX modulates glutamyl-tRNA reductase abundance to regulate heme biosynthesis (2018), mBio, 9, e02287-17 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.2.1.70

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-glutamate 1-semialdehyde + NADP+ + tRNAGlu Staphylococcus aureus
-
 L-glutamyl-tRNAGlu + NADPH + H+
-
 ?
L-glutamate 1-semialdehyde + NADP+ + tRNAGlu Staphylococcus aureus Newman
-
 L-glutamyl-tRNAGlu + NADPH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-
Staphylococcus aureus Newman
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamate 1-semialdehyde + NADP+ + tRNAGlu
-
 Staphylococcus aureus L-glutamyl-tRNAGlu + NADPH + H+
-
 ?
L-glutamate 1-semialdehyde + NADP+ + tRNAGlu
-
 Staphylococcus aureus Newman L-glutamyl-tRNAGlu + NADPH + H+
-
 ?

Synonyms

Synonyms Comment Organism
GtrR
-
 Staphylococcus aureus

Cofactor

Cofactor Comment Organism Structure
heme
-
 Staphylococcus aureus

Expression

Organism Comment Expression
Staphylococcus aureus enzyme abundance increases specifically in response to heme deficiency up

General Information

General Information Comment Organism
metabolism enzyme abundance as a critical regulator of Staphylococcus aureus heme synthesis. HemX controls enzyme abundance in heme-proficient cells to regulate heme synthesis Staphylococcus aureus