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Literature summary for 1.2.1.70 extracted from

  • Kang, Z.; Wang, Y.; Gu, P.; Wang, Q.; Qi, Q.
    Engineering Escherichia coli for efficient production of 5-aminolevulinic acid from glucose (2011), Metab. Eng., 13, 492-498.
    View publication on PubMed

Application

Application Comment Organism
biotechnology recombinant Escherichia coli allows efficient production of 5-aminolevulinic acid directly from glucose Salmonella enterica subsp. arizonae

Cloned(Commentary)

Cloned (Comment) Organism
hemA ligated into pUC19 vector with a Lys insert between Thr-2 and Leu-3 at N terminus, overexpression in Escherichia coli Salmonella enterica subsp. arizonae

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. arizonae
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamyl-tRNAGlu + NADPH + H+
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Salmonella enterica subsp. arizonae L-glutamate 1-semialdehyde + NADP+ + tRNAGlu
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?
additional information hemA with Lys insertion overexpressing Escherichia coli strain shows an increased 5-aminolevulinic acid accumulation indicating that the reduction of glutamyl-tRNA to glutamate-1-semialdehyde is a rate-limiting step Salmonella enterica subsp. arizonae ?
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?

Synonyms

Synonyms Comment Organism
GluRS
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Salmonella enterica subsp. arizonae
hemA
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Salmonella enterica subsp. arizonae