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Literature summary for 1.2.1.50 extracted from

  • Lee, C.Y.; Meighen, E.A.
    Cysteine-286 as the site of acylation of the lux-specific fatty acyl-CoA reductase (1997), Biochim. Biophys. Acta, 1338, 215-222.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Photobacterium phosphoreum
expression in Escherichia coli Photobacterium leiognathi

Protein Variants

Protein Variants Comment Organism
C171S acylation and specific activity similar to the wild-type Photobacterium phosphoreum
C171S acylation and specific activity similar to the wild-type Photobacterium leiognathi
C279S acylation and specific activity similar to the wild-type Photobacterium phosphoreum
C279S acylation and specific activity similar to the wild-type Photobacterium leiognathi
C286S no acylation and no activity Photobacterium phosphoreum
C286S no acylation and no activity Photobacterium leiognathi

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
tetradecanoyl-CoA + NADPH + H+ Photobacterium phosphoreum
-
tetradecanal + CoA + NADP+
-
?
tetradecanoyl-CoA + NADPH + H+ Photobacterium leiognathi
-
tetradecanal + CoA + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Photobacterium leiognathi
-
-
-
Photobacterium phosphoreum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
tetradecanoyl-CoA + NADPH + H+
-
Photobacterium phosphoreum tetradecanal + CoA + NADP+
-
?
tetradecanoyl-CoA + NADPH + H+
-
Photobacterium leiognathi tetradecanal + CoA + NADP+
-
?