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Literature summary for 1.2.1.5 extracted from
- Human salivary aldehyde dehydrogenase: purification, kinetic characterization and effect of ethanol, hydrogen peroxide and sodium dodecyl sulfate on the activity of the enzyme (2016), Cell Biochem. Biophys., 74, 307-315.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| ethanol | 0.05 mM, 1.8fold stimulation | Homo sapiens |  |
| H2O2 | 0.015 mM, 1.2fold stimulation | Homo sapiens | |
| Sodium dodecyl sulfate | 0.01 mM, 1.1fold stimulation | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0007 | - |
2-naphthaldehyde | pH 7.5, 25°C | Homo sapiens | |
| 0.0033 | - |
6-methoxy-2-naphthaldehyde | pH 7.5, 25°C | Homo sapiens | |
| 0.0053 | - |
cinnamaldehyde | pH 7.5, 25°C | Homo sapiens | |
| 0.148 | - |
benzaldehyde | pH 7.5, 25°C | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P30838 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| single-step purification | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| salivary gland | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-naphthaldehyde + NADH + H+ | - |
Homo sapiens | 2-naphthyl alcohol + NAD+ | - |
? | |
| 6-methoxy-2-naphthaldehyde + NADH + H+ | - |
Homo sapiens | (6-methoxynaphthalen-2-yl)methanol + NAD+ | - |
? | |
| benzaldehyde + NADH + H+ | - |
Homo sapiens | benzyl alcohol + NAD+ | - |
? | |
| cinnamaldehyde + NADH + H+ | - |
Homo sapiens | cinnamyl alcohol + NAD+ | - |
? | |
| additional information | enzyme follows a sequential mode of reaction mechanism | Homo sapiens | ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 45 | - |
- |
Homo sapiens |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
2 h, 34% residual activity | Homo sapiens |
| 50 | - |
7 min, almost complete inactivation | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
- |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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