BRENDA - Enzyme Database show
show all sequences of 1.2.1.5

Detoxification of promutagenic aldehydes derived from methylpyrenes by human aldehyde dehydrogenases ALDH2 and ALDH3A1

Glatt, H.; Rost, K.; Frank, H.; Seidel, A.; Kollock, R.; Arch. Biochem. Biophys. 477, 196-205 (2008)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expressed in Escherichia coli XL-1 cells
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.00078
-
4-formylpyrene
ALDH3A1, at pH 7.5 and 37C
Homo sapiens
0.0016
-
1-formyl-6-methylpyrene
ALDH3A1, at pH 7.5 and 37C
Homo sapiens
0.004
-
1-formyl-8-methylpyrene
ALDH3A1,at pH 7.5 and 37C
Homo sapiens
0.004
-
1-formylpyrene
ALDH3A1, at pH 7.5 and 37C
Homo sapiens
0.011
-
2-formylpyrene
ALDH3A1, at pH 7.5 and 37C
Homo sapiens
0.23
-
benzaldehyde
ALDH3A1, at pH 7.5 and 37C
Homo sapiens
12
-
propionaldehyde
ALDH3A1, at pH 7.5 and 37C
Homo sapiens
80
-
acetaldehyde
ALDH3A1, at pH 7.5 and 37C
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Homo sapiens
5739
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
P30838
-
-
Purification (Commentary)
Commentary
Organism
DEAE MacroPrep column chromatography
Homo sapiens
Source Tissue
Source Tissue
Commentary
Organism
Textmining
buccal mucosa
-
Homo sapiens
-
kidney
-
Homo sapiens
-
liver
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1-formyl-6-methylpyrene + NADP+ + H2O
-
684721
Homo sapiens
6-methylpyrene-1-carboxylic acid + NADPH + H+
-
-
-
?
1-formyl-8-methylpyrene + NADP+ + H2O
-
684721
Homo sapiens
8-methylpyrene-1-carboxylic acid + NADPH + H+
-
-
-
?
1-formylpyrene + NADP+ + H2O
-
684721
Homo sapiens
pyrene-1-carboxylic acid + NADPH + H+
-
-
-
?
2-formylpyrene + NADP+ + H2O
-
684721
Homo sapiens
pyrene-2-carboxylic acid + NADPH + H+
-
-
-
?
4-formylpyrene + NADP+ + H2O
-
684721
Homo sapiens
pyrene-4-carboxylic acid + NADPH + H+
-
-
-
?
acetaldehyde + NADP+ + H2O
-
684721
Homo sapiens
acetate + NADPH + H+
-
-
-
?
benzaldehyde + NADP+ + H2O
-
684721
Homo sapiens
benzoate + NADPH + H+
-
-
-
?
formaldehyde + NADP+ + H2O
-
684721
Homo sapiens
formate + NADPH + H+
-
-
-
?
propionaldehyde + NADP+ + H2O
-
684721
Homo sapiens
propionate + NADPH + H+
-
-
-
?
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8.5
-
-
Homo sapiens
pH Stability
pH Stability
pH Stability Maximum
Commentary
Organism
7.4
-
the activity at a physiological pH value (7.4) is nearly 50% of the activity observed at the optimal pH value
Homo sapiens
Cofactor
Cofactor
Commentary
Organism
Structure
NADP+
-
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
expressed in Escherichia coli XL-1 cells
Homo sapiens
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADP+
-
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.00078
-
4-formylpyrene
ALDH3A1, at pH 7.5 and 37C
Homo sapiens
0.0016
-
1-formyl-6-methylpyrene
ALDH3A1, at pH 7.5 and 37C
Homo sapiens
0.004
-
1-formyl-8-methylpyrene
ALDH3A1,at pH 7.5 and 37C
Homo sapiens
0.004
-
1-formylpyrene
ALDH3A1, at pH 7.5 and 37C
Homo sapiens
0.011
-
2-formylpyrene
ALDH3A1, at pH 7.5 and 37C
Homo sapiens
0.23
-
benzaldehyde
ALDH3A1, at pH 7.5 and 37C
Homo sapiens
12
-
propionaldehyde
ALDH3A1, at pH 7.5 and 37C
Homo sapiens
80
-
acetaldehyde
ALDH3A1, at pH 7.5 and 37C
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Homo sapiens
5739
-
Purification (Commentary) (protein specific)
Commentary
Organism
DEAE MacroPrep column chromatography
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
buccal mucosa
-
Homo sapiens
-
kidney
-
Homo sapiens
-
liver
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1-formyl-6-methylpyrene + NADP+ + H2O
-
684721
Homo sapiens
6-methylpyrene-1-carboxylic acid + NADPH + H+
-
-
-
?
1-formyl-8-methylpyrene + NADP+ + H2O
-
684721
Homo sapiens
8-methylpyrene-1-carboxylic acid + NADPH + H+
-
-
-
?
1-formylpyrene + NADP+ + H2O
-
684721
Homo sapiens
pyrene-1-carboxylic acid + NADPH + H+
-
-
-
?
2-formylpyrene + NADP+ + H2O
-
684721
Homo sapiens
pyrene-2-carboxylic acid + NADPH + H+
-
-
-
?
4-formylpyrene + NADP+ + H2O
-
684721
Homo sapiens
pyrene-4-carboxylic acid + NADPH + H+
-
-
-
?
acetaldehyde + NADP+ + H2O
-
684721
Homo sapiens
acetate + NADPH + H+
-
-
-
?
benzaldehyde + NADP+ + H2O
-
684721
Homo sapiens
benzoate + NADPH + H+
-
-
-
?
formaldehyde + NADP+ + H2O
-
684721
Homo sapiens
formate + NADPH + H+
-
-
-
?
propionaldehyde + NADP+ + H2O
-
684721
Homo sapiens
propionate + NADPH + H+
-
-
-
?
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8.5
-
-
Homo sapiens
pH Stability (protein specific)
pH Stability
pH Stability Maximum
Commentary
Organism
7.4
-
the activity at a physiological pH value (7.4) is nearly 50% of the activity observed at the optimal pH value
Homo sapiens
Other publictions for EC 1.2.1.5
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
735898
Alam
Human salivary aldehyde dehydr ...
Homo sapiens
Cell Biochem. Biophys.
74
307-315
2016
3
-
-
-
-
-
-
4
-
-
-
-
-
1
-
-
1
-
-
1
-
-
5
-
1
-
2
-
1
-
-
1
-
-
-
3
-
-
1
-
-
-
-
-
-
4
-
-
-
-
-
-
-
1
-
1
-
-
5
-
1
-
2
-
1
-
-
-
-
-
-
-
-
-
739913
Hong
Alternative biotransformation ...
Bacillus cereus, Bacillus cereus ATCC 10876
Appl. Environ. Microbiol.
82
3940-3946
2016
-
-
1
-
4
-
-
7
-
-
2
-
-
3
-
-
1
-
-
-
-
-
10
1
-
-
-
7
-
-
-
2
-
-
-
-
-
1
2
-
4
-
-
-
-
7
-
-
2
-
-
-
-
1
-
-
-
-
10
1
-
-
-
7
-
-
-
-
-
-
-
-
7
7
740279
Mali
Impaired ALDH2 activity decrea ...
Rattus norvegicus
Cell. Signal.
28
1-6
2016
-
-
-
-
-
-
2
-
1
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
741087
Tomita
Aldehyde dehydrogenase 1A1 in ...
Homo sapiens
Oncotarget
7
11018-11032
2016
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
741167
Jimenez-Lopez
-
Narrow-leafed lupin (Lupinus a ...
Lupinus angustifolius
Plant Gene
6
67-76
2016
-
-
-
-
-
-
-
-
5
-
-
2
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
5
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
740294
Gonzalez-Segura
Residues that influence coenzy ...
Sulfurisphaera tokodaii, Sulfurisphaera tokodaii DSM 16993
Chem. Biol. Interact.
234
59-74
2015
-
-
-
-
-
-
-
2
-
-
-
4
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
4
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
2
2
722210
Liu
Molecular characterization of ...
Sulfurisphaera tokodaii, Sulfurisphaera tokodaii 7
Extremophiles
17
181-190
2013
1
-
1
-
-
1
11
5
-
4
3
-
11
3
-
-
1
-
-
-
-
-
17
1
1
1
3
5
1
1
-
2
-
-
-
1
-
1
2
-
-
1
-
11
-
5
-
4
3
-
11
-
-
1
-
-
-
-
17
1
1
1
3
5
1
1
-
-
-
-
-
-
5
5
723877
Ngo
Expression, crystallization an ...
Bacillus cereus, Bacillus cereus ATCC 10876
Acta Crystallogr. Sect. F
69
528-531
2013
-
-
1
1
-
-
-
-
-
-
1
-
-
3
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
-
-
-
-
-
1
2
1
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
724620
Zhou
Production of 3-hydroxypropion ...
Klebsiella pneumoniae, Klebsiella pneumoniae DSM 2026
Biotechnol. Bioeng.
110
3177-3187
2013
-
1
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
724720
Gonzalez-Segura
Catalytic contribution of thre ...
Homo sapiens
Chem. Biol. Interact.
202
32-40
2013
-
-
1
1
4
-
-
10
1
1
1
2
-
1
-
-
1
-
-
-
-
-
2
1
-
-
-
10
-
-
-
1
-
-
-
-
-
1
1
1
4
-
-
-
-
10
1
1
1
2
-
-
-
1
-
-
-
-
2
1
-
-
-
10
-
-
-
-
-
-
-
-
10
10
725085
Zhou
Aldehyde dehydrogenase protein ...
Zea mays
Funct. Integr. Genomics
12
683-691
2012
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
1
1
2
-
-
747332
Aquino Neto
Development of nanostructured ...
Saccharomyces cerevisiae
Biosens. Bioelectron.
26
2922-2926
2011
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
711110
Koenig
Aldehyde dehydrogenase 1A3 is ...
Homo sapiens
Biochem. Biophys. Res. Commun.
400
207-211
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
711635
Stagos
Corneal aldehyde dehydrogenase ...
Mus musculus
Brain Res. Bull.
81
211-218
2010
-
-
-
-
-
-
-
-
1
-
-
2
-
1
-
-
-
-
-
2
-
-
2
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
2
-
-
2
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
725948
Lo
Gene cloning and biochemical c ...
Bacillus licheniformis, Bacillus licheniformis ATCC 14580
Mol. Biotechnol.
46
157-167
2010
2
-
1
-
-
-
15
10
-
1
3
-
-
3
-
-
1
-
-
-
-
-
17
1
1
-
1
10
1
-
1
2
-
-
-
2
-
1
2
-
-
-
-
15
-
10
-
1
3
-
-
-
-
1
-
-
-
-
17
1
1
-
1
10
1
-
1
-
-
-
-
-
10
10
698095
Gao
Evolutionary and expression st ...
Oryza sativa
Gene
431
86-94
2009
-
-
1
-
-
-
-
-
2
-
11
9
-
9
-
-
-
-
-
1
-
-
9
-
-
-
-
-
-
-
-
2
-
-
-
-
-
9
18
-
-
-
-
-
-
-
5
-
13
9
-
-
-
-
-
9
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
684586
Maestre
Effects of ADH2 overexpression ...
Lactobacillus casei BL23
Appl. Environ. Microbiol.
74
702-707
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
684721
Glatt
Detoxification of promutagenic ...
Homo sapiens
Arch. Biochem. Biophys.
477
196-205
2008
-
-
1
-
-
-
-
8
1
-
-
-
-
1
-
-
1
-
-
3
-
-
9
-
-
-
-
-
1
-
1
1
-
-
-
-
-
1
1
-
-
-
-
-
-
8
1
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9
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A point mutation produced a cl ...
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4
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Aldehyde dehydrogenase inhibit ...
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1
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8
1
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Non-P450 aldehyde oxidizing en ...
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Increased superoxide productio ...
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7
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5
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7
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A novel nicotinoprotein aldehy ...
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24
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1
1
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8
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1
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1
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1
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1
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24
1
1
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Paradoxical thermostable enzym ...
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1
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Thermostable aldehyde dehydrog ...
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2
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1
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3
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1
1
24
1
1
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348696
Izaguirre
Human aldehyde dehydrogenase c ...
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13
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9
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NAD(P)-dependent aldehyde dehy ...
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1
12
1
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655423
Boubekeur
Participation of acetaldehyde ...
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Shifting the NAD/NADP preferen ...
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Molecular cloning, characteriz ...
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348780
Downes
Purification and properties of ...
Mus musculus
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348782
King
Human corneal aldehyde dehydro ...
Homo sapiens
Biochem. Mol. Biol. Int.
31
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1993
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6
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6
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7
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6
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348784
Sreerama
Identification and characteriz ...
Homo sapiens
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348781
Choi
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Purification and characterizat ...
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Purification and characterizat ...
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Evces
Characterization of rat cornea ...
Rattus norvegicus
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3
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348786
Senior
Purification and characterizat ...
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1
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348789
Rietveld
Substituent effects during the ...
Rattus norvegicus, Saccharomyces cerevisiae
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27
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11
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348790
Lindahl
Characterization of aldehyde d ...
Rattus norvegicus
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180-185
1985
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348792
Eckfeldt
Isozymes of aldehyde dehydroge ...
Equus caballus
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348793
Tamaki
Aldehyde dehydrogenase from ba ...
Saccharomyces cerevisiae
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11
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Kinetics and reaction mechanis ...
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Horse liver aldehyde dehydroge ...
Equus caballus
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