BRENDA - Enzyme Database show
show all sequences of 1.2.1.5

Paradoxical thermostable enzymes from psychrophile: molecular characterization and potentiality for biotechnological application

Oikawa, T.; Kazuoka, T.; Soda, K.; J. Mol. Catal. B 23, 65-70 (2003)
No PubMed abstract available

Data extracted from this reference:

Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Cytophaga sp.
-
KUC-1, psychrophile isolated from antarctic seawater
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acetaldehyde + NAD(P)+ + H2O
51% of activity with benzaldehyde
656571
Cytophaga sp.
acetate + NAD(P)H + H+
-
-
-
ir
benzaldehyde + NAD+ + H2O
pro-R specific
656571
Cytophaga sp.
benzoate + NADH + H+
-
-
-
ir
benzaldehyde + NADP+ + H2O
25% of activity with NAD+
656571
Cytophaga sp.
benzoate + NADPH
-
-
-
ir
butyraldehyde + NAD(P)+ + H2O
23% of activity with benzaldehyde
656571
Cytophaga sp.
butanoate + NAD(P)H + H+
-
-
-
ir
DL-glyceraldehyde + NAD(P)+ + H2O
14% of activity with benzaldehyde
656571
Cytophaga sp.
glycerate + NAD(P)H + H+
-
-
-
ir
formaldehyde + NAD(P)+ + H2O
52% of activity with benzaldehyde
656571
Cytophaga sp.
formate + NAD(P)H + H+
-
-
-
ir
heptylaldehyde + NAD(P)+ + H2O
12% of activity with benzaldehyde
656571
Cytophaga sp.
heptanoate + NAD(P)H + H+
-
-
-
ir
hexylaldehyde + NAD(P)+ + H2O
22% of activity with benzaldehyde
656571
Cytophaga sp.
hexanoate + NAD(P)H + H+
-
-
-
ir
isobutyraldehyde + NAD(P)+ + H2O
188% of activity with benzaldehyde
656571
Cytophaga sp.
isobutanoate + NAD(P)H + H+
-
-
-
ir
isovaleraldehyde + NAD(P)+ + H2O
83% of activity with benzaldehyde
656571
Cytophaga sp.
isovalerate + NAD(P)H
-
-
-
ir
m-bromobenzaldehyde + NAD(P)+ + H2O
28% of activity with benzaldehyde
656571
Cytophaga sp.
m-bromobenzoate + NAD(P)H + H+
-
-
-
ir
m-chlorobenzaldehyde + NAD(P)+ + H2O
35% of activity with benzaldehyde
656571
Cytophaga sp.
m-chlorobenzoate + NAD(P)H + H+
-
-
-
ir
m-fluorobenzaldehyde + NAD(P)+ + H2O
41% of activity with benzaldehyde
656571
Cytophaga sp.
m-fluorobenzoate + NAD(P)H + H+
-
-
-
ir
o-fluorobenzaldehyde + NAD(P)+ + H2O
100% of activity with benzaldehyde
656571
Cytophaga sp.
o-fluorobenzoate + NAD(P)H + H+
-
-
-
ir
o-methoxybenzaldehyde + NAD(P)+ + H2O
18% of activity with benzaldehyde
656571
Cytophaga sp.
o-methoxybenzoate + NAD(P)H + H+
-
-
-
ir
octylaldehyde + NAD(P)+ + H2O
10% of activity with benzaldehyde
656571
Cytophaga sp.
octanoate + NAD(P)H + H+
-
-
-
ir
p-bromobenzaldehyde + NAD(P)+ + H2O
14% of activity with benzaldehyde
656571
Cytophaga sp.
p-bromobenzoate + NAD(P)H + H+
-
-
-
ir
p-chlorobenzaldehyde + NAD(P)+ + H2O
35% of activity with benzaldehyde
656571
Cytophaga sp.
p-chlorobenzoate + NAD(P)H + H+
-
-
-
ir
p-fluorobenzaldehyde + NAD(P)+ + H2O
75% of activity with benzaldehyde
656571
Cytophaga sp.
p-fluorobenzoate + NAD(P)H + H+
-
-
-
ir
p-isopropylbenzaldehyde + NAD(P)+ + H2O
15% of activity with benzaldehyde
656571
Cytophaga sp.
p-isopropylbenzoate + NAD(P)H + H+
-
-
-
ir
propionaldehyde + NAD(P)+ + H2O
75% of activity with benzaldehyde
656571
Cytophaga sp.
propionate + NAD(P)H
-
-
-
ir
valeraldehyde + NAD(P)+ + H2O
16.3% of activity with benzaldehyde
656571
Cytophaga sp.
valerate + NAD(P)H + H+
-
-
-
ir
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
55
-
-
Cytophaga sp.
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acetaldehyde + NAD(P)+ + H2O
51% of activity with benzaldehyde
656571
Cytophaga sp.
acetate + NAD(P)H + H+
-
-
-
ir
benzaldehyde + NAD+ + H2O
pro-R specific
656571
Cytophaga sp.
benzoate + NADH + H+
-
-
-
ir
benzaldehyde + NADP+ + H2O
25% of activity with NAD+
656571
Cytophaga sp.
benzoate + NADPH
-
-
-
ir
butyraldehyde + NAD(P)+ + H2O
23% of activity with benzaldehyde
656571
Cytophaga sp.
butanoate + NAD(P)H + H+
-
-
-
ir
DL-glyceraldehyde + NAD(P)+ + H2O
14% of activity with benzaldehyde
656571
Cytophaga sp.
glycerate + NAD(P)H + H+
-
-
-
ir
formaldehyde + NAD(P)+ + H2O
52% of activity with benzaldehyde
656571
Cytophaga sp.
formate + NAD(P)H + H+
-
-
-
ir
heptylaldehyde + NAD(P)+ + H2O
12% of activity with benzaldehyde
656571
Cytophaga sp.
heptanoate + NAD(P)H + H+
-
-
-
ir
hexylaldehyde + NAD(P)+ + H2O
22% of activity with benzaldehyde
656571
Cytophaga sp.
hexanoate + NAD(P)H + H+
-
-
-
ir
isobutyraldehyde + NAD(P)+ + H2O
188% of activity with benzaldehyde
656571
Cytophaga sp.
isobutanoate + NAD(P)H + H+
-
-
-
ir
isovaleraldehyde + NAD(P)+ + H2O
83% of activity with benzaldehyde
656571
Cytophaga sp.
isovalerate + NAD(P)H
-
-
-
ir
m-bromobenzaldehyde + NAD(P)+ + H2O
28% of activity with benzaldehyde
656571
Cytophaga sp.
m-bromobenzoate + NAD(P)H + H+
-
-
-
ir
m-chlorobenzaldehyde + NAD(P)+ + H2O
35% of activity with benzaldehyde
656571
Cytophaga sp.
m-chlorobenzoate + NAD(P)H + H+
-
-
-
ir
m-fluorobenzaldehyde + NAD(P)+ + H2O
41% of activity with benzaldehyde
656571
Cytophaga sp.
m-fluorobenzoate + NAD(P)H + H+
-
-
-
ir
o-fluorobenzaldehyde + NAD(P)+ + H2O
100% of activity with benzaldehyde
656571
Cytophaga sp.
o-fluorobenzoate + NAD(P)H + H+
-
-
-
ir
o-methoxybenzaldehyde + NAD(P)+ + H2O
18% of activity with benzaldehyde
656571
Cytophaga sp.
o-methoxybenzoate + NAD(P)H + H+
-
-
-
ir
octylaldehyde + NAD(P)+ + H2O
10% of activity with benzaldehyde
656571
Cytophaga sp.
octanoate + NAD(P)H + H+
-
-
-
ir
p-bromobenzaldehyde + NAD(P)+ + H2O
14% of activity with benzaldehyde
656571
Cytophaga sp.
p-bromobenzoate + NAD(P)H + H+
-
-
-
ir
p-chlorobenzaldehyde + NAD(P)+ + H2O
35% of activity with benzaldehyde
656571
Cytophaga sp.
p-chlorobenzoate + NAD(P)H + H+
-
-
-
ir
p-fluorobenzaldehyde + NAD(P)+ + H2O
75% of activity with benzaldehyde
656571
Cytophaga sp.
p-fluorobenzoate + NAD(P)H + H+
-
-
-
ir
p-isopropylbenzaldehyde + NAD(P)+ + H2O
15% of activity with benzaldehyde
656571
Cytophaga sp.
p-isopropylbenzoate + NAD(P)H + H+
-
-
-
ir
propionaldehyde + NAD(P)+ + H2O
75% of activity with benzaldehyde
656571
Cytophaga sp.
propionate + NAD(P)H
-
-
-
ir
valeraldehyde + NAD(P)+ + H2O
16.3% of activity with benzaldehyde
656571
Cytophaga sp.
valerate + NAD(P)H + H+
-
-
-
ir
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
55
-
-
Cytophaga sp.
Other publictions for EC 1.2.1.5
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
735898
Alam
Human salivary aldehyde dehydr ...
Homo sapiens
Cell Biochem. Biophys.
74
307-315
2016
3
-
-
-
-
-
-
4
-
-
-
-
-
1
-
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1
-
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1
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5
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1
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2
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1
-
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1
-
-
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3
-
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1
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4
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1
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1
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5
-
1
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2
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1
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-
-
-
-
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-
739913
Hong
Alternative biotransformation ...
Bacillus cereus, Bacillus cereus ATCC 10876
Appl. Environ. Microbiol.
82
3940-3946
2016
-
-
1
-
4
-
-
7
-
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2
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3
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1
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-
-
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10
1
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7
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2
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1
2
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4
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7
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2
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1
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-
10
1
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-
7
-
-
-
-
-
-
-
-
7
7
740279
Mali
Impaired ALDH2 activity decrea ...
Rattus norvegicus
Cell. Signal.
28
1-6
2016
-
-
-
-
-
-
2
-
1
-
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1
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2
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2
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-
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741087
Tomita
Aldehyde dehydrogenase 1A1 in ...
Homo sapiens
Oncotarget
7
11018-11032
2016
-
1
-
-
-
-
-
-
-
-
-
-
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1
-
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-
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2
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2
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1
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2
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-
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-
-
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-
-
-
1
1
-
-
-
741167
Jimenez-Lopez
-
Narrow-leafed lupin (Lupinus a ...
Lupinus angustifolius
Plant Gene
6
67-76
2016
-
-
-
-
-
-
-
-
5
-
-
2
-
1
-
-
-
-
-
-
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2
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-
-
-
-
-
-
2
-
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2
-
-
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5
-
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2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
740294
Gonzalez-Segura
Residues that influence coenzy ...
Sulfolobus tokodaii, Sulfolobus tokodaii DSM 16993
Chem. Biol. Interact.
234
59-74
2015
-
-
-
-
-
-
-
2
-
-
-
4
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
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2
-
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-
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-
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2
-
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2
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4
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-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
2
2
722210
Liu
Molecular characterization of ...
Sulfolobus tokodaii, Sulfolobus tokodaii 7
Extremophiles
17
181-190
2013
1
-
1
-
-
1
11
5
-
4
3
-
11
3
-
-
1
-
-
-
-
-
17
1
1
1
3
5
1
1
-
2
-
-
-
1
-
1
2
-
-
1
-
11
-
5
-
4
3
-
11
-
-
1
-
-
-
-
17
1
1
1
3
5
1
1
-
-
-
-
-
-
5
5
723877
Ngo
Expression, crystallization an ...
Bacillus cereus, Bacillus cereus ATCC 10876
Acta Crystallogr. Sect. F
69
528-531
2013
-
-
1
1
-
-
-
-
-
-
1
-
-
3
-
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1
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-
-
-
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1
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2
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1
2
1
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1
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1
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1
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-
-
-
-
-
-
-
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-
724620
Zhou
Production of 3-hydroxypropion ...
Klebsiella pneumoniae, Klebsiella pneumoniae DSM 2026
Biotechnol. Bioeng.
110
3177-3187
2013
-
1
-
-
-
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-
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5
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1
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2
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2
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1
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2
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
724720
Gonzalez-Segura
Catalytic contribution of thre ...
Homo sapiens
Chem. Biol. Interact.
202
32-40
2013
-
-
1
1
4
-
-
10
1
1
1
2
-
1
-
-
1
-
-
-
-
-
2
1
-
-
-
10
-
-
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1
-
-
-
-
-
1
1
1
4
-
-
-
-
10
1
1
1
2
-
-
-
1
-
-
-
-
2
1
-
-
-
10
-
-
-
-
-
-
-
-
10
10
725085
Zhou
Aldehyde dehydrogenase protein ...
Zea mays
Funct. Integr. Genomics
12
683-691
2012
-
-
-
-
-
-
-
-
-
-
-
-
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1
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2
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2
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-
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-
-
-
-
-
-
-
2
1
1
2
-
-
711110
Koenig
Aldehyde dehydrogenase 1A3 is ...
Homo sapiens
Biochem. Biophys. Res. Commun.
400
207-211
2010
-
-
-
-
-
-
-
-
-
-
-
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1
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4
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1
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1
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4
-
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-
-
-
-
-
-
-
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-
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1
-
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1
-
-
711635
Stagos
Corneal aldehyde dehydrogenase ...
Mus musculus
Brain Res. Bull.
81
211-218
2010
-
-
-
-
-
-
-
-
1
-
-
2
-
1
-
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2
-
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2
1
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2
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2
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1
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2
-
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2
-
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2
1
-
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-
-
-
-
-
-
-
1
1
-
-
-
725948
Lo
Gene cloning and biochemical c ...
Bacillus licheniformis, Bacillus licheniformis ATCC 14580
Mol. Biotechnol.
46
157-167
2010
2
-
1
-
-
-
15
10
-
1
3
-
-
3
-
-
1
-
-
-
-
-
17
1
1
-
1
10
1
-
1
2
-
-
-
2
-
1
2
-
-
-
-
15
-
10
-
1
3
-
-
-
-
1
-
-
-
-
17
1
1
-
1
10
1
-
1
-
-
-
-
-
10
10
698095
Gao
Evolutionary and expression st ...
Oryza sativa
Gene
431
86-94
2009
-
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1
-
-
-
-
-
2
-
11
9
-
9
-
-
-
-
-
1
-
-
9
-
-
-
-
-
-
-
-
2
-
-
-
-
-
9
18
-
-
-
-
-
-
-
5
-
13
9
-
-
-
-
-
9
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
684586
Maestre
Effects of ADH2 overexpression ...
Lactobacillus casei BL23
Appl. Environ. Microbiol.
74
702-707
2008
-
-
-
-
-
-
-
-
-
-
-
-
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1
-
-
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-
-
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1
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-
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5
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7
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Paradoxical thermostable enzym ...
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Thermostable aldehyde dehydrog ...
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Izaguirre
Human aldehyde dehydrogenase c ...
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Participation of acetaldehyde ...
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Downes
Purification and properties of ...
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King
Human corneal aldehyde dehydro ...
Homo sapiens
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Sreerama
Identification and characteriz ...
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Purification and characterizat ...
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Purification and characterizat ...
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Characterization of rat cornea ...
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Purification and characterizat ...
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Substituent effects during the ...
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Lindahl
Characterization of aldehyde d ...
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Tamaki
Aldehyde dehydrogenase from ba ...
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12
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-