BRENDA - Enzyme Database show
show all sequences of 1.2.1.5

Kinetics and reaction mechanism of potassium-activated aldehyde dehydrogenase from Saccharomyces cerevisiae

Bostian, K.A.; Betts, G.F.; Biochem. J. 173, 787-798 (1978)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
Benzoate
non-competitive with respect to either NAD+ or benzaldehyde
Saccharomyces cerevisiae
NADH
competitive with respect to NAD+ and non-competitive with respect to either benzaldehyde or glycolaldehyde
Saccharomyces cerevisiae
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
-
Saccharomyces cerevisiae
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Saccharomyces cerevisiae
-
-
-
Reaction
Reaction
Commentary
Organism
an aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H + H+
ordered bi bi mechanism with NAD+ as the leading substrate
Saccharomyces cerevisiae
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
benzaldehyde + NAD+ + H2O
-
348795
Saccharomyces cerevisiae
benzoate + NADH + H+
-
-
-
?
glycolaldehyde + NAD+
-
348795
Saccharomyces cerevisiae
glycolate + NADH
-
-
-
?
glycolaldehyde + NADP+ + H2O
-
348795
Saccharomyces cerevisiae
glycolate + NADPH + H+
-
-
-
?
Temperature Stability [C]
Temperature Stability Minimum [C]
Temperature Stability Maximum [C]
Commentary
Organism
25
-
60 min, about 60% loss of activity without stabilizer, about 10% loss of activity in presence of 5 mM NAD+; 70 min, about 80% loss of activity without stabilizer, about 15% loss of activity in presence of 50 mM KCl; 90 min, about 80% loss of activity without a stabilizer, about 20% loss of activity in presence of 24% v/v of ethanediol
Saccharomyces cerevisiae
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
Benzoate
non-competitive with respect to either NAD+ or benzaldehyde
Saccharomyces cerevisiae
NADH
competitive with respect to NAD+ and non-competitive with respect to either benzaldehyde or glycolaldehyde
Saccharomyces cerevisiae
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
-
Saccharomyces cerevisiae
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
benzaldehyde + NAD+ + H2O
-
348795
Saccharomyces cerevisiae
benzoate + NADH + H+
-
-
-
?
glycolaldehyde + NAD+
-
348795
Saccharomyces cerevisiae
glycolate + NADH
-
-
-
?
glycolaldehyde + NADP+ + H2O
-
348795
Saccharomyces cerevisiae
glycolate + NADPH + H+
-
-
-
?
Temperature Stability [C] (protein specific)
Temperature Stability Minimum [C]
Temperature Stability Maximum [C]
Commentary
Organism
25
-
60 min, about 60% loss of activity without stabilizer, about 10% loss of activity in presence of 5 mM NAD+; 70 min, about 80% loss of activity without stabilizer, about 15% loss of activity in presence of 50 mM KCl; 90 min, about 80% loss of activity without a stabilizer, about 20% loss of activity in presence of 24% v/v of ethanediol
Saccharomyces cerevisiae
Other publictions for EC 1.2.1.5
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
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3
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4
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1
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739913
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4
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7
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10
1
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7
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7
7
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2
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1
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741087
Tomita
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7
11018-11032
2016
-
1
-
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2
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1
1
-
-
-
741167
Jimenez-Lopez
-
Narrow-leafed lupin (Lupinus a ...
Lupinus angustifolius
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6
67-76
2016
-
-
-
-
-
-
-
-
5
-
-
2
-
1
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5
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2
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2
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-
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-
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-
740294
Gonzalez-Segura
Residues that influence coenzy ...
Sulfolobus tokodaii, Sulfolobus tokodaii DSM 16993
Chem. Biol. Interact.
234
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2015
-
-
-
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-
-
-
2
-
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4
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2
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4
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2
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2
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2
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4
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4
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-
2
2
722210
Liu
Molecular characterization of ...
Sulfolobus tokodaii, Sulfolobus tokodaii 7
Extremophiles
17
181-190
2013
1
-
1
-
-
1
11
5
-
4
3
-
11
3
-
-
1
-
-
-
-
-
17
1
1
1
3
5
1
1
-
2
-
-
-
1
-
1
2
-
-
1
-
11
-
5
-
4
3
-
11
-
-
1
-
-
-
-
17
1
1
1
3
5
1
1
-
-
-
-
-
-
5
5
723877
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Bacillus cereus, Bacillus cereus ATCC 10876
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69
528-531
2013
-
-
1
1
-
-
-
-
-
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1
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3
-
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1
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1
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2
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1
2
1
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1
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1
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1
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-
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-
-
724620
Zhou
Production of 3-hydroxypropion ...
Klebsiella pneumoniae, Klebsiella pneumoniae DSM 2026
Biotechnol. Bioeng.
110
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2013
-
1
-
-
-
-
-
-
-
-
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5
-
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1
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2
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2
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1
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2
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1
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2
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-
-
-
-
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-
-
-
-
-
724720
Gonzalez-Segura
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Homo sapiens
Chem. Biol. Interact.
202
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2013
-
-
1
1
4
-
-
10
1
1
1
2
-
1
-
-
1
-
-
-
-
-
2
1
-
-
-
10
-
-
-
1
-
-
-
-
-
1
1
1
4
-
-
-
-
10
1
1
1
2
-
-
-
1
-
-
-
-
2
1
-
-
-
10
-
-
-
-
-
-
-
-
10
10
725085
Zhou
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Zea mays
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12
683-691
2012
-
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1
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-
-
-
-
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2
1
1
2
-
-
711110
Koenig
Aldehyde dehydrogenase 1A3 is ...
Homo sapiens
Biochem. Biophys. Res. Commun.
400
207-211
2010
-
-
-
-
-
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-
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1
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4
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1
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1
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4
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-
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1
-
-
1
-
-
711635
Stagos
Corneal aldehyde dehydrogenase ...
Mus musculus
Brain Res. Bull.
81
211-218
2010
-
-
-
-
-
-
-
-
1
-
-
2
-
1
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2
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2
1
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2
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2
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1
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2
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2
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2
1
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-
-
-
-
-
-
-
1
1
-
-
-
725948
Lo
Gene cloning and biochemical c ...
Bacillus licheniformis, Bacillus licheniformis ATCC 14580
Mol. Biotechnol.
46
157-167
2010
2
-
1
-
-
-
15
10
-
1
3
-
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3
-
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1
-
-
-
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-
17
1
1
-
1
10
1
-
1
2
-
-
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2
-
1
2
-
-
-
-
15
-
10
-
1
3
-
-
-
-
1
-
-
-
-
17
1
1
-
1
10
1
-
1
-
-
-
-
-
10
10
698095
Gao
Evolutionary and expression st ...
Oryza sativa
Gene
431
86-94
2009
-
-
1
-
-
-
-
-
2
-
11
9
-
9
-
-
-
-
-
1
-
-
9
-
-
-
-
-
-
-
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2
-
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-
9
18
-
-
-
-
-
-
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5
-
13
9
-
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-
-
9
-
-
9
-
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-
-
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-
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-
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-
-
-
-
684586
Maestre
Effects of ADH2 overexpression ...
Lactobacillus casei BL23
Appl. Environ. Microbiol.
74
702-707
2008
-
-
-
-
-
-
-
-
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1
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1
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1
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-
684721
Glatt
Detoxification of promutagenic ...
Homo sapiens
Arch. Biochem. Biophys.
477
196-205
2008
-
-
1
-
-
-
-
8
1
-
-
-
-
1
-
-
1
-
-
3
-
-
9
-
-
-
-
-
1
-
1
1
-
-
-
-
-
1
1
-
-
-
-
-
-
8
1
-
-
-
-
-
-
1
-
3
-
-
9
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
685040
Ho
A point mutation produced a cl ...
Homo sapiens
Biochem. Pharmacol.
76
690-696
2008
-
-
1
-
1
-
-
-
-
-
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-
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2
-
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1
-
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1
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4
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1
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1
1
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1
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1
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1
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4
-
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686531
Quash
Aldehyde dehydrogenase inhibit ...
Homo sapiens
Eur. J. Med. Chem.
43
906-916
2008
-
-
-
-
-
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2
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4
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4
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1
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1
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1
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4
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1
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688414
Bajns J.
Structural and biochemical cha ...
Paraburkholderia xenovorans, Paraburkholderia xenovorans LB400
J. Mol. Biol.
379
597-608
2008
-
-
1
1
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8
-
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1
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2
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1
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8
1
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2
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1
2
1
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8
-
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1
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1
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8
1
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-
690142
Alnouti
Tissue distribution, ontogeny, ...
Mus musculus
Toxicol. Sci.
101
51-64
2008
-
-
-
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-
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2
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3
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15
-
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3
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1
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-
-
-
-
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3
-
-
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6
-
-
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45
-
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3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
692251
Marchitti
Non-P450 aldehyde oxidizing en ...
Homo sapiens
Expert. Opin. Drug Metab. Toxicol.
4
697-720
2008
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
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1
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1
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1
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1
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-
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-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688446
Szoecs
Increased superoxide productio ...
Rattus norvegicus, Saccharomyces cerevisiae
J. Mol. Cell. Cardiol.
42
1111-1118
2007
-
2
-
-
-
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2
-
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2
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3
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2
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2
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3
-
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2
-
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-
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-
689379
Marchitti
Neurotoxicity and metabolism o ...
Homo sapiens
Pharmacol. Rev.
59
125-150
2007
-
-
-
-
-
-
1
5
3
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24
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8
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24
1
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22
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Thermostable aldehyde dehydrog ...
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1
24
1
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Human aldehyde dehydrogenase c ...
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9
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1
12
1
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655423
Boubekeur
Participation of acetaldehyde ...
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1
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Shifting the NAD/NADP preferen ...
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6
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348783
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Molecular cloning, characteriz ...
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348780
Downes
Purification and properties of ...
Mus musculus
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7
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7
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348782
King
Human corneal aldehyde dehydro ...
Homo sapiens
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6
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7
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348784
Sreerama
Identification and characteriz ...
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348781
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Purification and characterizat ...
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Purification and characterizat ...
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Evces
Characterization of rat cornea ...
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Purification and characterizat ...
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348789
Rietveld
Substituent effects during the ...
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Lindahl
Characterization of aldehyde d ...
Rattus norvegicus
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Eckfeldt
Isozymes of aldehyde dehydroge ...
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348793
Tamaki
Aldehyde dehydrogenase from ba ...
Saccharomyces cerevisiae
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Kinetics and reaction mechanis ...
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Purification and properties of ...
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Eckfeldt
Horse liver aldehyde dehydroge ...
Equus caballus
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