Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Saccharomyces cerevisiae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ZnCl2 | 50% inhibition at 0.035 mM, enzyme form ALDH1 | Saccharomyces cerevisiae |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.01 | - |
acetaldehyde | reaction with NADP+, enzyme form ALDH2 | Saccharomyces cerevisiae | |
0.013 | - |
propanal | reaction with NAD+, enzyme form ALDH2 | Saccharomyces cerevisiae | |
0.017 | - |
propanal | reaction with NADP+, enzyme form ALDH2 | Saccharomyces cerevisiae | |
0.024 | - |
acetaldehyde | reaction with NADP+, enzyme form ALDH1 | Saccharomyces cerevisiae | |
0.03 | - |
propanal | reaction with NADP+, enzyme form ALDH1 | Saccharomyces cerevisiae | |
0.04 | - |
NADP+ | reaction with acetaldehyde, enzyme form ALDH1 | Saccharomyces cerevisiae | |
0.058 | - |
acetaldehyde | reaction with NADP+, enzyme form ALDH5 | Saccharomyces cerevisiae | |
0.099 | - |
NADP+ | reaction with propanal, enzyme form ALDH1 | Saccharomyces cerevisiae | |
0.39 | - |
propanal | reaction with NADP+, enzyme form ALDH5 | Saccharomyces cerevisiae | |
0.447 | - |
NADP+ | reaction with propanal, enzyme form ALDH2 | Saccharomyces cerevisiae | |
0.64 | - |
NADP+ | reaction with acetaldehyde, enzyme form ALDH5 | Saccharomyces cerevisiae | |
0.7 | - |
propanal | reaction with NAD+, enzyme form ALDH1 | Saccharomyces cerevisiae | |
0.83 | - |
propanal | reaction with NAD+, enzyme form ALDH5 | Saccharomyces cerevisiae | |
1.1 | - |
NAD+ | reaction with propanal, enzyme form ALDH2 | Saccharomyces cerevisiae | |
1.4 | - |
NADP+ | reaction with acetaldehyde, enzyme form ALDH2 | Saccharomyces cerevisiae | |
3.47 | - |
NADP+ | reaction with propanal, enzyme form ALDH5 | Saccharomyces cerevisiae | |
6.43 | - |
NAD+ | reaction with propanal, enzyme form ALDH5 | Saccharomyces cerevisiae | |
17.4 | - |
NAD+ | reaction with propanal, enzyme form ALDH1 | Saccharomyces cerevisiae |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | enzyme form ALDH1 | Saccharomyces cerevisiae | 5829 | - |
mitochondrion | enzyme form ALDH5 | Saccharomyces cerevisiae | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
CaCl2 | 30 mM, 3.8fold stimulation of activity of ALDH1 | Saccharomyces cerevisiae | |
KCl | 120 mM: 40fold increase of activity of ALDH5 with NAD+. 16 mM: 20fold increase of activity of enzyme ALDH5 with NADP+. No stimulation of the activity of enzyme form ALDH1 | Saccharomyces cerevisiae | |
Mg2+ | 20 mM MgCl2, 2.8fold stimulation of activity of ALDH1 | Saccharomyces cerevisiae | |
MnCl2 | 2 mM, 2.1fold stimulation of activity of ALDH1 | Saccharomyces cerevisiae |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
53904 | - |
x * 53904, enzyme form ALDH5, mass spectrometric analysis | Saccharomyces cerevisiae |
54570 | - |
x * 54570, enzyme form ALDH1, mass spectrometric analysis | Saccharomyces cerevisiae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
ALDH1, ALDH2 and ALDH5 | - |
Purification (Comment) | Organism |
---|---|
- |
Saccharomyces cerevisiae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetaldehyde + NAD+ + H2O | - |
Saccharomyces cerevisiae | acetate + NADH + H+ | - |
? | |
benzaldehyde + NAD+ + H2O | ALDH2 is very active, low activity with ALDH1 and ALDH5 | Saccharomyces cerevisiae | benzoate + NADH + H+ | - |
? | |
propanal + NAD+ + H2O | - |
Saccharomyces cerevisiae | propionate + NADH + H+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 53904, enzyme form ALDH5, mass spectrometric analysis | Saccharomyces cerevisiae |
? | x * 54570, enzyme form ALDH1, mass spectrometric analysis | Saccharomyces cerevisiae |