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show all sequences of 1.2.1.49

Methylglyoxal metabolism and diabetic complications: roles of aldose reductase, glyoxalase-I, betaine aldehyde dehydrogenase and 2-oxoaldehyde dehydrogenase

Vander Jagt, D.L.; Hunsaker, L.A.; Chem. Biol. Interact. 143-144, 341-351 (2003)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
Amines
several amines stimulate activity
Homo sapiens
DL-2-amino-1-propanol
required, best activator of the reaction
Homo sapiens
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
40000
-
SDS-PAGE
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
methylglyoxal + NADP+ + H2O
Homo sapiens
contributes to the detoxification of methylglyoxal
pyruvate + NADPH
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Purification (Commentary)
Commentary
Organism
-
Homo sapiens
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
methylglyoxal + NADP+ + H2O
-
655211
Homo sapiens
pyruvate + NADPH
-
-
-
?
methylglyoxal + NADP+ + H2O
contributes to the detoxification of methylglyoxal
655211
Homo sapiens
pyruvate + NADPH
-
-
-
?
Subunits
Subunits
Commentary
Organism
monomer
-
Homo sapiens
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
9.5
-
-
Homo sapiens
pH Range
pH Minimum
pH Maximum
Commentary
Organism
8.5
10
very low activity at physiological pH
Homo sapiens
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
Amines
several amines stimulate activity
Homo sapiens
DL-2-amino-1-propanol
required, best activator of the reaction
Homo sapiens
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
40000
-
SDS-PAGE
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
methylglyoxal + NADP+ + H2O
Homo sapiens
contributes to the detoxification of methylglyoxal
pyruvate + NADPH
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
-
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
methylglyoxal + NADP+ + H2O
-
655211
Homo sapiens
pyruvate + NADPH
-
-
-
?
methylglyoxal + NADP+ + H2O
contributes to the detoxification of methylglyoxal
655211
Homo sapiens
pyruvate + NADPH
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
monomer
-
Homo sapiens
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
9.5
-
-
Homo sapiens
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
8.5
10
very low activity at physiological pH
Homo sapiens
Other publictions for EC 1.2.1.49
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
655211
Vander Jagt
Methylglyoxal metabolism and d ...
Homo sapiens
Chem. Biol. Interact.
143-144
341-351
2003
2
-
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-
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-
-
-
1
1
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1
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1
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1
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2
1
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1
1
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2
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-
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-
-
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-
1
1
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1
-
1
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2
1
-
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1
1
-
-
-
-
-
-
-
-
288148
Bender
Biochemical genetics of methyl ...
Rattus norvegicus
Biochem. Genet.
32
147-154
1994
-
-
1
-
-
-
-
-
-
-
-
1
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1
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-
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-
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3
-
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2
-
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-
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2
-
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-
1
2
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-
-
-
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-
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1
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3
-
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2
-
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-
-
-
-
-
-
-
-
-
-
-
-
288140
Ray
Purification and characterizat ...
Capra hircus
J. Biol. Chem.
257
10566-10570
1982
-
-
-
-
-
-
-
3
-
-
2
1
-
1
-
-
1
-
-
1
1
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2
1
-
-
-
-
1
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1
-
-
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-
-
-
1
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-
-
-
-
-
3
-
-
2
1
-
-
-
1
-
1
1
-
2
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
288141
Ray
On the interaction of nucleoti ...
Capra hircus
J. Biol. Chem.
257
10571-10574
1982
-
-
-
-
-
-
1
1
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1
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1
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2
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1
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1
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1
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1
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1
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2
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
288256
Vander Jagt
2-Ketoaldehyde dehydrogenase f ...
Rattus norvegicus
Methods Enzymol.
89
513-515
1982
2
-
-
-
-
-
-
-
-
-
-
1
-
1
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1
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1
1
1
2
-
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-
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-
1
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2
-
-
1
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-
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-
1
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1
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1
1
1
2
-
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-
-
-
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-
-
-
-
-
-
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-
288259
Vander Jagt
Purification and characterizat ...
Rattus norvegicus
Biochim. Biophys. Acta
484
260-267
1977
2
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-
-
-
-
4
-
-
1
1
-
1
-
-
1
-
-
1
2
1
2
-
-
-
-
-
1
1
1
1
-
-
-
2
-
-
1
-
-
-
-
-
-
4
-
-
1
1
-
-
-
1
-
1
2
1
2
-
-
-
-
-
1
1
1
-
-
-
-
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-
-
288142
Dunkerton
Some observations on the NADP+ ...
Ovis aries
Biochem. J.
153
503-504
1976
1
-
-
-
-
-
-
4
-
-
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1
-
1
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-
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-
-
1
1
-
3
-
-
-
-
-
-
-
-
2
-
-
-
1
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2
-
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4
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1
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-
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1
1
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3
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-
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-
-
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-
-
-
-
-
-
-
288143
Dunkerton
Purification of 2-oxoaldehyde ...
Ovis aries
Biochem. J.
149
609-617
1975
7
-
-
-
-
-
2
-
-
-
-
1
-
1
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-
1
-
-
1
-
1
4
-
-
-
-
-
1
1
-
2
-
-
-
7
-
-
2
-
-
-
-
2
-
-
-
-
-
1
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-
-
1
-
1
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1
4
-
-
-
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-
1
1
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-
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-
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-
288145
Jellum
Metabolism of the ketoaldehyde ...
Ovis aries, Rattus norvegicus
Biochim. Biophys. Acta
165
357-363
1968
-
-
-
-
-
-
-
2
-
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4
-
2
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1
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2
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6
-
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4
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4
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2
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4
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1
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2
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6
-
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-
-
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-
-
-
-
-
-
-
-
-
288146
Monder
alpha-Keto aldehyde dehydrogen ...
Ovis aries
J. Biol. Chem.
242
4603-4609
1967
-
-
-
-
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8
3
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1
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1
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1
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2
1
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2
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3
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3
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3
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8
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3
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1
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1
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2
1
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2
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3
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