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Literature summary for 1.2.1.49 extracted from

  • Vander Jagt, D.L.; Hunsaker, L.A.
    Methylglyoxal metabolism and diabetic complications: roles of aldose reductase, glyoxalase-I, betaine aldehyde dehydrogenase and 2-oxoaldehyde dehydrogenase (2003), Chem. Biol. Interact., 143-144, 341-351.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Amines several amines stimulate activity Homo sapiens
DL-2-amino-1-propanol required, best activator of the reaction Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
methylglyoxal + NADP+ + H2O Homo sapiens contributes to the detoxification of methylglyoxal pyruvate + NADPH
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
methylglyoxal + NADP+ + H2O
-
Homo sapiens pyruvate + NADPH
-
?
methylglyoxal + NADP+ + H2O contributes to the detoxification of methylglyoxal Homo sapiens pyruvate + NADPH
-
?

Subunits

Subunits Comment Organism
monomer
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9.5
-
-
Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
8.5 10 very low activity at physiological pH Homo sapiens