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Literature summary for 1.2.1.47 extracted from

  • Matsunaga, A.; Harita, Y.; Shibagaki, Y.; Shimizu, N.; Shibuya, K.; Ono, H.; Kato, H.; Sekine, T.; Sakamoto, N.; Igarashi, T.; Hattori, S.
    Identification of 4-trimethylaminobutyraldehyde dehydrogenase (TMABA-DH) as a candidate serum autoantibody target for Kawasaki disease (2015), PLoS ONE, 10, e0128189 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.2.1.47

Application

Application Comment Organism
diagnostics detection of anti-TMABA-DH autoantibody is a potential strategy for a diagnosis of Kawasaki disease, usefulness of the anti-TMABA-DH antibody as a diagnostic marker Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
recombinant expression of FLAG-tagged enzyme TMABA-DH in HEK-293T cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-trimethylammoniobutanal + NAD+ + H2O Homo sapiens
-
 4-trimethylammoniobutanoate + NADH + 2 H+
-
 ?
4-trimethylammoniobutanal + NAD+ + H2O Rattus norvegicus
-
 4-trimethylammoniobutanoate + NADH + 2 H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P49189
-
-
Rattus norvegicus Q9JLJ3
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant FLAG-tagged enzyme TMABA-DH from HEK-293T cells by immunoaffinity chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
artery
-
 Homo sapiens
-
cardiac myocyte
-
 Rattus norvegicus
-
heart
-
 Homo sapiens
-
heart enzyme TMABA-DH colocalizes with myosin light chains in cardiac myocytes Rattus norvegicus
-
HUVEC cell
-
 Homo sapiens
-
additional information alpha-Smooth muscle actin, a marker for endothelial cells, does not colocalize with TMABA-DH signals. The rat enzyme can be detected wit ant-human TMABA-DH antibodies in rat hearts Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-trimethylammoniobutanal + NAD+ + H2O
-
 Homo sapiens 4-trimethylammoniobutanoate + NADH + 2 H+
-
 ?
4-trimethylammoniobutanal + NAD+ + H2O
-
 Rattus norvegicus 4-trimethylammoniobutanoate + NADH + 2 H+
-
 ?

Synonyms

Synonyms Comment Organism
4-trimethylaminobutyraldehyde dehydrogenase
-
 Homo sapiens
4-trimethylaminobutyraldehyde dehydrogenase
-
 Rattus norvegicus
TMABA-DH
-
 Homo sapiens
TMABA-DH
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens
NAD+
-
 Rattus norvegicus

General Information

General Information Comment Organism
malfunction enzyme overexpression causes the Kawasaki disease (KD), an acute vasculitis that preferentially affects coronary arteries. The disease is still the leading cause of acquired heart disease in children. Patients suffering Kawasaki disease show increased TMABADH enzyme protein levels compared to controls Homo sapiens