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Literature summary for 1.2.1.46 extracted from

  • Zhu, G.; Yu, G.; Zhang, X.; Liu, J.; Zhang, Y.; Rollins, J.A.; Li, J.; Pan, H.
    The formaldehyde dehydrogenase SsFdh1 is regulated by and functionally cooperates with the GATA transcription factor SsNsd1 in Sclerotinia sclerotiorum (2019), mSystems, 4, e00397-19 .
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Sclerotinia sclerotiorum 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ contains zinc Sclerotinia sclerotiorum

Organism

Organism UniProt Comment Textmining
Sclerotinia sclerotiorum
-
 isolate 1980 (UF-70)
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Synonyms

Synonyms Comment Organism
FDH1
-
 Sclerotinia sclerotiorum
Glutathione-dependent formaldehyde dehydrogenase
-
 Sclerotinia sclerotiorum

Cofactor

Cofactor Comment Organism Structure
glutathione
-
 Sclerotinia sclerotiorum
NAD+
-
 Sclerotinia sclerotiorum

General Information

General Information Comment Organism
physiological function the enzyme functions in formaldehyde detoxification, sodium nitroprusside tolerance, nitrogen metabolism, sclerotium development, and pathogenicity. The enzyme is regulated by and functions jointly with the Nsd1 GATA transcription factor. The enzyme prevents Nsd1 binding to DNA. The enzyme is important in osmotic stress (such as 1 M KCl, 1 M NaCl, or 1 M sorbitol) and oxidative stress (20 mM H2O2) resistance Sclerotinia sclerotiorum