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Literature summary for 1.2.1.46 extracted from

  • Sunga, A.J.; Cregg, J.M.
    The Pichia pastoris formaldehyde dehydrogenase gene (FLD1) as a marker for selection of multicopy expression strains of P. pastoris (2004), Gene, 330, 39-47.
    View publication on PubMed
Search for more literature for 1.2.1.46

Application

Application Comment Organism
analysis presence of enzyme can be used as a selectable marker in DNA-mediated transformations Komagataella pastoris

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ two ions bound per subunit Komagataella pastoris

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
formaldehyde + NAD+ + H2O Komagataella pastoris required for growth on methanol as carbon source or methylamine as nitrogen source, reaction provides energy as NADH and protects against a toxic excess of formaldehyde formate + NADH
-
 ?
formaldehyde + NAD+ + H2O Komagataella pastoris NRRL Y-11430 required for growth on methanol as carbon source or methylamine as nitrogen source, reaction provides energy as NADH and protects against a toxic excess of formaldehyde formate + NADH
-
 ?

Organism

Organism UniProt Comment Textmining
Komagataella pastoris
-
 methylotrophic yeast
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Komagataella pastoris NRRL Y-11430
-
 methylotrophic yeast
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
formaldehyde + NAD+ + H2O
-
 Komagataella pastoris formate + NADH
-
 ?
formaldehyde + NAD+ + H2O required for growth on methanol as carbon source or methylamine as nitrogen source, reaction provides energy as NADH and protects against a toxic excess of formaldehyde Komagataella pastoris formate + NADH
-
 ?
formaldehyde + NAD+ + H2O
-
 Komagataella pastoris NRRL Y-11430 formate + NADH
-
 ?
formaldehyde + NAD+ + H2O required for growth on methanol as carbon source or methylamine as nitrogen source, reaction provides energy as NADH and protects against a toxic excess of formaldehyde Komagataella pastoris NRRL Y-11430 formate + NADH
-
 ?

Cofactor

Cofactor Comment Organism Structure
NAD+ tightly but not covalently bound to protein Komagataella pastoris