Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cholesterol | - |
Mus musculus | |
additional information | 22(R)-hydroxy cholesterol elevates significantly the RALDH2 mRNA level in H2.35 cells | Mus musculus | |
additional information | dexamethasone, little effect on RALDH expression | Mus musculus | |
additional information | oxysterols, cholesterol metabolites, induce the RALDH1 gene via upregulation of sterol regulatory element binding protein-1c, SREBP-1c | Mus musculus | |
additional information | oxysterols, cholesterol metabolites, induce the RALDH2 gene via upregulation of sterol regulatory element binding protein-1c, SREBP-1c | Mus musculus |
Cloned (Comment) | Organism |
---|---|
expressed in COS-1 cells | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
pravastatin sodium | cholesterol-lowering agent downregulates the expression of RALDH1,2 genes | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
retinal + NAD+ + H2O | Mus musculus | - |
retinoate + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
H2.35 cell | - |
Mus musculus | - |
heart | - |
Mus musculus | - |
kidney | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
Neuro-2a cell | - |
Mus musculus | - |
P-19 cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
retinal + NAD+ + H2O | - |
Mus musculus | retinoate + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
RalDH1 | - |
Mus musculus |
RALDH2 | - |
Mus musculus |
Retinal dehydrogenase | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Mus musculus |