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Literature summary for 1.2.1.36 extracted from

  • Dupe, V.; Matt, N.; Garnier, J.M.; Chambon, P.; Mark, M.; Ghyselinck, N.B.
    A newborn lethal defect due to inactivation of retinaldehyde dehydrogenase type 3 is prevented by maternal retinoic acid treatment (2003), Proc. Natl. Acad. Sci. USA, 100, 14036-14041.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.2.1.36

Protein Variants

Protein Variants Comment Organism
additional information construction of isozyme type-3 knock-out mice with suppressed retinoic acid biosynthesis, showing malformations restricted to ocular and nasal regions and choanal atresia, i.e. CA, leading to respiratory distress and death of mutant mice after birth, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
9-cis-retinal + NAD+ + H2O Mus musculus step in biosynthesis of vitamin A, transduction by nuclear retinoid receptors, required for ontogenesis and homeostasis of numerous tissues 9-cis-retinoate + NADH
-
 ?
all-trans-retinal + NAD+ + H2O Mus musculus step in biosynthesis of vitamin A, transduction by nuclear retinoid receptors, required for ontogenesis and homeostasis of numerous tissues all-trans-retinoate + NADH
-
 ?
additional information Mus musculus physiological function, newborn lethal defect due to isozyme type-3 inactivation is prevented by maternal retinoic acid treatment, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 isozyme type-3
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
9-cis-retinal + NAD+ + H2O
-
 Mus musculus 9-cis-retinoate + NADH
-
 ?
9-cis-retinal + NAD+ + H2O step in biosynthesis of vitamin A, transduction by nuclear retinoid receptors, required for ontogenesis and homeostasis of numerous tissues Mus musculus 9-cis-retinoate + NADH
-
 ?
all-trans-retinal + NAD+ + H2O
-
 Mus musculus all-trans-retinoate + NADH
-
 ?
all-trans-retinal + NAD+ + H2O step in biosynthesis of vitamin A, transduction by nuclear retinoid receptors, required for ontogenesis and homeostasis of numerous tissues Mus musculus all-trans-retinoate + NADH
-
 ?
additional information physiological function, newborn lethal defect due to isozyme type-3 inactivation is prevented by maternal retinoic acid treatment, overview Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
RALDH
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Mus musculus