Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Lys | - |
Acremonium chrysogenum | |
Lys | - |
Penicillium chrysogenum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-2-aminoadipate + NADPH + H+ | Penicillium chrysogenum | key enzyme in the branched pathway for lysine and beta-lactam biosynthesis of filamentous fungi. Nitrate has a strong negative effect on enzyme formation | L-2-aminoadipate 6-semialdehyde + NADP+ + H2O | - |
? | |
L-2-aminoadipate + NADPH + H+ | Acremonium chrysogenum | key enzyme in the branched pathway for lysine and beta-lactam biosynthesis of filamentous fungi. Nitrate has a strong negative effect on enzyme formation | L-2-aminoadipate 6-semialdehyde + NADP+ + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Acremonium chrysogenum | - |
wild-type strain ATCC 11550 and the improved cephalosporin producer strain C10, ATC 48272 | - |
Penicillium chrysogenum | - |
wild-type strain NRRL 1951 and a low-penicillin-producing strain Wis 54-1255 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cell culture | the activity peaks during growth-phase preceding the onset of antibiotic production, which coincides with a decrease in enzyme activity, and is lower in high cephalosporin-producing strains | Acremonium chrysogenum | - |
cell culture | the activity peaks during growth-phase preceding the onset of antibiotic production, which coincides with a decrease in enzyme activity, and is lower in high penicillin-producing strains | Penicillium chrysogenum | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-2-aminoadipate + NADPH + H+ | - |
Penicillium chrysogenum | L-2-aminoadipate 6-semialdehyde + NADP+ + H2O | - |
? | |
L-2-aminoadipate + NADPH + H+ | - |
Acremonium chrysogenum | L-2-aminoadipate 6-semialdehyde + NADP+ + H2O | - |
? | |
L-2-aminoadipate + NADPH + H+ | key enzyme in the branched pathway for lysine and beta-lactam biosynthesis of filamentous fungi. Nitrate has a strong negative effect on enzyme formation | Penicillium chrysogenum | L-2-aminoadipate 6-semialdehyde + NADP+ + H2O | - |
? | |
L-2-aminoadipate + NADPH + H+ | key enzyme in the branched pathway for lysine and beta-lactam biosynthesis of filamentous fungi. Nitrate has a strong negative effect on enzyme formation | Acremonium chrysogenum | L-2-aminoadipate 6-semialdehyde + NADP+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
alpha-AAR | - |
Penicillium chrysogenum |
alpha-AAR | - |
Acremonium chrysogenum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | no activity with NADH | Penicillium chrysogenum | |
NADPH | no activity with NADH | Acremonium chrysogenum |