delta1-piperideine-6-carboxylic acid and alpha-aminoadipic acid delta-semialdehyde

Data extracted from this reference:

Inhibitors

Commentary

Organism

Structure

ATP

30% inhibition at 1 mM

Pseudomonas putida

carbonyl reagents

e.g.: hydroxylamine, KCN, in the presence of substrate

Pseudomonas putida

HSO3-

in presence of substrate

Pseudomonas putida

hydroxylamine

in presence of substrate

Pseudomonas putida

KCN

in presence of substrate

Pseudomonas putida

KM Value [mM]

KM Value Maximum [mM]

Substrate

Commentary

Organism

Structure

0.002

-

DELTA1-piperidine 6-carboxylate

-

Pseudomonas putida

Natural Substrates

Organism

Commentary (Nat. Sub.)

Natural Products

Commentary (Nat. Pro.)

Organism (Nat. Pro.)

Reversibility

ID

L-2-aminoadipate-semialdehyde + NAD+

Pseudomonas putida

degradative enzyme

L-2-aminoadipate + NADH

-

Pseudomonas putida

?

Substrates

Commentary Substrates

Literature (Substrates)

Organism

Products

Commentary (Products)

Literature (Products)

Organism (Products)

Reversibility

Substrate Product ID

(S)-2,3,4,5-tetrahydropyridine-2-carboxylate + NAD+ + H2O

-

288194

Pseudomonas putida

L-2-aminoadipate + NADH

-

288194

Pseudomonas putida

ir

L-2-aminoadipate 6-semialdehyde + NAD+ + H2O

-

288194

Pseudomonas putida

L-2-aminoadipate + NADH

-

288194

Pseudomonas putida

ir

L-2-aminoadipate-semialdehyde + NAD+

degradative enzyme

288194

Pseudomonas putida

L-2-aminoadipate + NADH

-

288194

Pseudomonas putida

?

Cofactor

Commentary

Organism

Structure

NAD+

-

Pseudomonas putida

Cofactor

Commentary

Organism

Structure

NAD+

-

Pseudomonas putida

Inhibitors

Commentary

Organism

Structure

ATP

30% inhibition at 1 mM

Pseudomonas putida

carbonyl reagents

e.g.: hydroxylamine, KCN, in the presence of substrate

Pseudomonas putida

HSO3-

in presence of substrate

Pseudomonas putida

hydroxylamine

in presence of substrate

Pseudomonas putida

KCN

in presence of substrate

Pseudomonas putida

KM Value [mM]

KM Value Maximum [mM]

Substrate

Commentary

Organism

Structure

0.002

-

DELTA1-piperidine 6-carboxylate

-

Pseudomonas putida

Natural Substrates

Organism

Commentary (Nat. Sub.)

Natural Products

Commentary (Nat. Pro.)

Organism (Nat. Pro.)

Reversibility

ID

L-2-aminoadipate-semialdehyde + NAD+

Pseudomonas putida

degradative enzyme

L-2-aminoadipate + NADH

-

Pseudomonas putida

?

Substrates

Commentary Substrates

Literature (Substrates)

Organism

Products

Commentary (Products)

Literature (Products)

Organism (Products)

Reversibility

ID

(S)-2,3,4,5-tetrahydropyridine-2-carboxylate + NAD+ + H2O

-

288194

Pseudomonas putida

L-2-aminoadipate + NADH

-

288194

Pseudomonas putida

ir

L-2-aminoadipate 6-semialdehyde + NAD+ + H2O

-

288194

Pseudomonas putida

L-2-aminoadipate + NADH

-

288194

Pseudomonas putida

ir

L-2-aminoadipate-semialdehyde + NAD+

degradative enzyme

288194

Pseudomonas putida

L-2-aminoadipate + NADH

-

288194

Pseudomonas putida

?

No.

1st author

Pub Med

title

organims

journal

volume

pages

year

Activating Compound

Application

Cloned(Commentary)

Crystallization (Commentary)

Engineering

General Stability

Inhibitors

KM Value [mM]

Localization

Metals/Ions

Molecular Weight [Da]

Natural Substrates/ Products (Substrates)

Organic Solvent Stability

Organism

Oxidation Stability

Posttranslational Modification

Purification (Commentary)

Reaction

Renatured (Commentary)

Source Tissue

Specific Activity [micromol/min/mg]

Storage Stability

Substrates and Products (Substrate)

Subunits

Synonyms

Temperature Optimum [°C]

Temperature Range [°C]

Temperature Stability [°C]

Turnover Number [1/s]

pH Optimum

pH Range

pH Stability

Cofactor

Ki Value [mM]

pI Value

IC50 Value

Activating Compound (protein specific)

Application (protein specific)

Cloned(Commentary) (protein specific)

Cofactor (protein specific)

Crystallization (Commentary) (protein specific)

Engineering (protein specific)

General Stability (protein specific)

IC50 Value (protein specific)

Inhibitors (protein specific)

Ki Value [mM] (protein specific)

KM Value [mM] (protein specific)

Localization (protein specific)

Metals/Ions (protein specific)

Molecular Weight [Da] (protein specific)

Natural Substrates/ Products (Substrates) (protein specific)

Organic Solvent Stability (protein specific)

Oxidation Stability (protein specific)

Posttranslational Modification (protein specific)

Purification (Commentary) (protein specific)

Renatured (Commentary) (protein specific)

Source Tissue (protein specific)

Specific Activity [micromol/min/mg] (protein specific)

Storage Stability (protein specific)

Substrates and Products (Substrate) (protein specific)

Subunits (protein specific)

Temperature Optimum [°C] (protein specific)

Temperature Range [°C] (protein specific)

Temperature Stability [°C] (protein specific)

Turnover Number [1/s] (protein specific)

pH Optimum (protein specific)

pH Range (protein specific)

pH Stability (protein specific)

pI Value (protein specific)

Expression

General Information

General Information (protein specific)

Expression (protein specific)

KCat/KM [mM/s]

KCat/KM [mM/s] (protein specific)

712017

Struys

Metabolism of lysine in alpha- ...

Homo sapiens

FEBS Lett.

584

181-186

2010

-

-

-

-

-

-

-

-

-

-

-

-

-

1

-

-

-

-

-

1

-

-

1

-

3

-

-

-

-

-

-

-

1

-

-

-

-

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

1

-

-

1

-

-

-

-

-

-

-

-

-

-

1

1

-

-

-

690142

Alnouti

Tissue distribution, ontogeny, ...

Mus musculus

Toxicol. Sci.

101

51-64

2008

-

-

-

-

-

-

-

-

2

-

-

-

-

1

-

-

-

-

-

15

-

-

1

-

1

-

-

-

-

-

-

-

1

-

-

-

-

-

-

1

-

-

-

-

-

-

-

2

-

-

-

-

-

-

-

-

15

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

693281

Isobe

Analysis of selective producti ...

Rhodococcus sp., Rhodococcus sp. AIU Z-35-1

J. Biosci. Bioeng.

105

152-156

2008

-

-

-

-

-

-

2

2

-

-

-

-

-

4

-

-

1

-

-

-

1

-

2

-

1

1

1

1

-

1

1

1

-

2

-

-

-

-

-

-

-

-

-

-

2

2

2

-

-

-

-

-

-

-

1

-

-

1

-

2

-

1

1

1

-

1

1

1

-

-

-

-

-

-

-

689379

Marchitti

Neurotoxicity and metabolism o ...

Homo sapiens

Pharmacol. Rev.

59

125-150

2007

-

-

-

-

-

-

1

-

1

-

-

-

-

1

-

-

-

-

-

2

-

-

1

-

1

-

-

-

-

-

-

-

1

-

-

-

-

-

-

1

-

-

-

-

1

-

-

1

-

-

-

-

-

-

-

-

2

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

694191

Struys

Alpha-aminoadipic semialdehyde ...

Homo sapiens

Mol. Genet. Metab.

91

405

2007

-

1

-

-

1

-

-

-

-

-

-

-

-

1

-

-

-

-

-

-

-

-

-

-

2

-

-

-

-

-

-

-

-

-

-

-

-

1

-

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

675897

Wang

Cloning and characterization o ...

Homo sapiens

Mol. Biol. Rep.

32

47-53

2005

-

-

1

-

-

-

-

-

-

-

-

1

-

3

-

-

-

-

-

24

-

-

1

-

4

-

-

-

-

-

-

-

1

-

-

-

-

-

1

1

-

-

-

-

-

-

-

-

-

-

1

-

-

-

-

-

24

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

676142

Felton

Biochemistry: role of PQQ as a ...

Mammalia

Nature

433

E10

2005

-

-

-

-

-

-

-

-

-

-

-

-

-

1

-

-

-

-

-

-

-

-

-

-

2

-

-

-

-

-

-

-

1

-

-

-

-

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

676143

Rucker

Biochemistry: Is pyrroloquinol ...

Mus musculus, Rattus norvegicus

Nature

433

E10-1

2005

-

-

-

-

-

-

-

-

-

-

-

-

-

2

-

-

-

-

-

2

-

-

-

-

6

-

-

-

-

-

-

-

2

-

-

-

-

-

-

2

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

2

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

657420

Guo

Posttranslational activation, ...

Schizosaccharomyces pombe

Yeast

21

1279-1288

2004

1

-

1

-

16

-

-

-

-

-

-

1

-

7

-

-

1

-

-

-

-

-

2

-

3

-

-

-

-

-

-

-

1

-

-

-

1

-

1

1

-

16

-

-

-

-

-

-

-

-

1

-

-

-

1

-

-

-

-

2

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

656194

Hijarrubia

Domain structure characterizat ...

Penicillium chrysogenum

J. Biol. Chem.

278

8250-8256

2003

1

-

-

-

-

-

1

3

-

2

2

-

-

2

-

-

1

-

-

-

1

1

2

1

-

1

-

3

1

1

-

-

1

-

-

-

1

-

-

1

-

-

-

-

1

-

3

-

2

2

-

-

-

-

1

-

-

1

1

2

1

1

-

3

1

1

-

-

-

-

-

-

-

-

-

657417

Alberti

LYS2 gene and its mutation in ...

Kluyveromyces lactis

Yeast

20

1171-1175

2003

-

-

1

-

-

-

-

-

-

-

-

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

654293

Hijarrubia

Nitrate regulation of alpha-am ...

Acremonium chrysogenum, Penicillium chrysogenum

Appl. Microbiol. Biotechnol.

59

270-277

2002

-

-

-

-

-

-

2

-

-

-

-

2

-

7

-

-

-

-

-

2

-

-

4

-

2

-

-

-

-

-

-

-

2

-

-

-

-

-

-

2

-

-

-

-

2

-

-

-

-

-

2

-

-

-

-

-

2

-

-

4

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

288202

Praphanphoj

Identification of the.alpha-Am ...

Homo sapiens

Mol. Genet. Metab.

72

336-342

2001

-

-

1

-

-

-

-

-

-

-

-

-

-

1

-

1

-

-

-

16

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

1

-

-

16

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

288203

Hijarrubia

Characterization of the lys2 g ...

Acremonium chrysogenum

Mol. Gen. Genet.

264

755-762

2001

-

-

1

-

-

-

-

-

-

-

-

2

-

1

-

1

-

-

-

-

1

-

3

-

-

-

-

-

-

-

-

-

2

-

-

-

-

-

1

2

-

-

-

-

-

-

-

-

-

-

2

-

-

1

-

-

-

1

-

3

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

288204

Guo

Novel posttranslational activa ...

Candida albicans

J. Bacteriol.

183

7120-7125

2001

-

-

1

-

-

-

-

-

-

-

-

1

-

1

-

2

-

-

-

-

1

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

1

-

-

-

-

-

-

-

-

-

-

-

1

-

-

2

-

-

-

1

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

288201

Ehmann

Lysine biosynthesis in Sacchar ...

Saccharomyces cerevisiae

Biochemistry

38

6171-6177

1999

-

-

1

-

-

-

-

1

-

-

2

1

-

1

-

2

-

-

-

-

-

-

3

-

-

-

-

-

1

-

-

-

-

-

-

-

-

-

1

-

-

-

-

-

-

-

1

-

-

2

1

-

-

2

-

-

-

-

-

3

-

-

-

-

1

-

-

-

-

-

-

-

-

-

-

288199

Suvarna

Molecular analysis of the LYS2 ...

Candida albicans, Saccharomyces cerevisiae

Curr. Genet.

33

268-275

1998

-

-

1

-

-

-

3

-

-

-

-

-

-

2

-

-

-

-

-

-

2

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

1

-

-

-

-

-

3

-

-

-

-

-

-

-

-

-

-

-

-

2

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

288200

Casqueiro

Characterization of the lys2 g ...

Penicillium chrysogenum

Mol. Gen. Genet.

259

549-556

1998

-

-

1

-

-

-

-

-

-

-

1

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

1

-

-

-

-

-

-

-

-

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

288198

Ford

Molecular properties of the ly ...

Saccharomyces cerevisiae, Schizosaccharomyces pombe

Curr. Genet.

28

131-137

1995

-

-

1

-

-

-

2

-

-

-

-

-

-

2

-

-

-

-

-

-

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

1

-

-

-

-

-

2

-

-

-

-

-

-

-

-

-

-

-

-

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

288185

Schmidt

Inhibition of alpha-aminoadipa ...

Blastobotrys adeninivorans

FEMS Microbiol. Lett.

70

41-44

1990

-

-

-

-

-

-

3

4

-

1

-

2

-

2

-

-

1

-

-

-

1

-

4

-

-

-

-

-

-

1

-

-

1

3

-

-

-

-

-

1

-

-

-

-

3

3

4

-

1

-

2

-

-

-

1

-

-

1

-

4

-

-

-

-

-

1

-

-

-

-

-

-

-

-

-

288186

Chang

L-pipecolic acid metabolism in ...

Homo sapiens

Biochim. Biophys. Acta

1038

300-305

1990

3

-

-

-

-

-

5

2

1

3

-

-

-

3

-

-

-

-

-

2

1

1

1

-

-

-

-

-

-

1

-

-

1

-

-

-

3

-

-

1

-

-

-

-

5

-

2

1

3

-

-

-

-

-

-

-

2

1

1

1

-

-

-

-

-

1

-

-

-

-

-

-

-

-

-

288187

Samsonova

Auxotrophic mutants of the yea ...

Blastobotrys adeninivorans

J. Basic Microbiol.

29

675-683

1989

-

-

-

-

7

-

-

-

-

-

-

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

7

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

288188

Schmidt

-

Isolation and characterization ...

Candida maltosa, Meyerozyma guilliermondii

FEMS Microbiol. Lett.

60

201-204

1989

-

-

-

-

-

-

-

-

-

-

-

-

-

2

-

-

-

-

-

-

6

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

6

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

288189

Storts

Properties of revertants of ly ...

Saccharomyces cerevisiae

Biochem. Biophys. Res. Commun.

161

182-186

1989

-

-

1

-

-

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288190

Ye

Lysine biosynthesis pathway an ...

Schizosaccharomyces pombe

J. Bacteriol.

170

5968-5970

1988

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288196

Fleig

Construction of LYS2 cartridge ...

Saccharomyces cerevisiae

Gene

46

237-245

1986

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1

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1

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288197

Barnes

Genetic manipulation of Saccha ...

Saccharomyces cerevisiae

Mol. Cell. Biol.

6

2828-2838

1986

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1

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288192

Schmidt

-

Lysine biosynthesis in the yea ...

Candida maltosa

J. Basic Microbiol.

25

675-681

1985

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6

5

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1

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8

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288191

Eibel

Identification of the cloned S ...

Saccharomyces cerevisiae

Mol. Gen. Genet.

191

66-73

1983

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288193

Tsai

Degradation of O-phosphohydrox ...

Rattus norvegicus

J. Biol. Chem.

249

5790-5792

1974

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288194

Rodwell

-

delta1-piperideine-6-carboxyli ...

Pseudomonas putida

Methods Enzymol.

17B

188-199

1971

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5

1

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288195

Calvert

Metabolism of pipecolic acid i ...

Pseudomonas sp.

J. Biol. Chem.

241

409-414

1966

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11

1

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