Cloned (Comment) | Organism |
---|---|
expression by a baculovirus system | Homo sapiens |
expression by a baculovirus system | Oryctolagus cuniculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0021 | - |
4-hydroxynonenal | pH 8.0, 25°C | Oryctolagus cuniculus | |
0.0035 | - |
hexanal | pH 8.0, 25°C | Oryctolagus cuniculus | |
0.0134 | - |
hexanal | pH 8.0, 25°C | Homo sapiens | |
0.014 | - |
malondialdehyde | pH 8.0, 25°C | Oryctolagus cuniculus | |
0.0179 | - |
4-hydroxynonenal | pH 8.0, 25°C | Homo sapiens | |
0.0662 | - |
propionaldehyde | pH 8.0, 25°C | Oryctolagus cuniculus | |
0.1144 | - |
malondialdehyde | pH 8.0, 25°C | Homo sapiens | |
0.1372 | - |
propionaldehyde | pH 8.0, 25°C | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
54000 | - |
x * 54000, SDS-PAGE | Homo sapiens |
54000 | - |
x * 54000, SDS-PAGE | Oryctolagus cuniculus |
54340 | - |
x * 54340, calculation from nucleotide sequence | Oryctolagus cuniculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme may contribute to corneal cellular defense against oxidative damage by metabolizing toxic aldehydes produced during UV-induced lipid peroxidation | ? | - |
? | |
additional information | Oryctolagus cuniculus | the enzyme may contribute to corneal cellular defense against oxidative damage by metabolizing toxic aldehydes produced during UV-induced lipid peroxidation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
- |
Oryctolagus cuniculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
corneal epithelium | - |
Homo sapiens | - |
corneal epithelium | - |
Oryctolagus cuniculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.2341 | - |
substrate: propionaldehyde, pH 8.0, 25°C | Homo sapiens |
0.5337 | - |
substrate: propionaldehyde, pH 8.0, 25°C | Oryctolagus cuniculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-hydroxynonenal + NAD+ + H2O | - |
Oryctolagus cuniculus | 4-hydroxynonanoate + NADH | - |
? | |
4-hydroxynonenal + NAD+ + H2O | - |
Homo sapiens | 4-hydroxynonanoate + NADH + H+ | - |
? | |
hexanal + NAD+ + H2O | - |
Homo sapiens | hexanoate + NADH + H+ | - |
? | |
hexanal + NAD+ + H2O | - |
Oryctolagus cuniculus | hexanoate + NADH + H+ | - |
? | |
malondialdehyde + NAD+ + H2O | - |
Homo sapiens | ? + NADH | - |
? | |
malondialdehyde + NAD+ + H2O | - |
Oryctolagus cuniculus | ? + NADH | - |
? | |
additional information | the enzyme may contribute to corneal cellular defense against oxidative damage by metabolizing toxic aldehydes produced during UV-induced lipid peroxidation | Homo sapiens | ? | - |
? | |
additional information | the enzyme may contribute to corneal cellular defense against oxidative damage by metabolizing toxic aldehydes produced during UV-induced lipid peroxidation | Oryctolagus cuniculus | ? | - |
? | |
propanal + NAD+ + H2O | - |
Oryctolagus cuniculus | propionate + NADH | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 54000, SDS-PAGE | Homo sapiens |
? | x * 54000, SDS-PAGE | Oryctolagus cuniculus |
? | x * 54340, calculation from nucleotide sequence | Oryctolagus cuniculus |
Synonyms | Comment | Organism |
---|---|---|
ALDH1A1 | - |
Homo sapiens |
ALDH1A1 | - |
Oryctolagus cuniculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens | |
NAD+ | - |
Oryctolagus cuniculus |