Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.2.1.3 extracted from

  • Manzer, R.; Qamar, L.; Estey, T.; Pappa, A.; Petersen, D.R.; Vasiliou, V.
    Molecular cloning and baculovirus expression of the rabbit corneal aldehyde dehydrogenase (ALDH1A1) cDNA (2003), DNA Cell Biol., 22, 329-338.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression by a baculovirus system Homo sapiens
expression by a baculovirus system Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0021
-
4-hydroxynonenal pH 8.0, 25°C Oryctolagus cuniculus
0.0035
-
hexanal pH 8.0, 25°C Oryctolagus cuniculus
0.0134
-
hexanal pH 8.0, 25°C Homo sapiens
0.014
-
malondialdehyde pH 8.0, 25°C Oryctolagus cuniculus
0.0179
-
4-hydroxynonenal pH 8.0, 25°C Homo sapiens
0.0662
-
propionaldehyde pH 8.0, 25°C Oryctolagus cuniculus
0.1144
-
malondialdehyde pH 8.0, 25°C Homo sapiens
0.1372
-
propionaldehyde pH 8.0, 25°C Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
54000
-
x * 54000, SDS-PAGE Homo sapiens
54000
-
x * 54000, SDS-PAGE Oryctolagus cuniculus
54340
-
x * 54340, calculation from nucleotide sequence Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme may contribute to corneal cellular defense against oxidative damage by metabolizing toxic aldehydes produced during UV-induced lipid peroxidation ?
-
?
additional information Oryctolagus cuniculus the enzyme may contribute to corneal cellular defense against oxidative damage by metabolizing toxic aldehydes produced during UV-induced lipid peroxidation ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Oryctolagus cuniculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens
-
Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
corneal epithelium
-
Homo sapiens
-
corneal epithelium
-
Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.2341
-
substrate: propionaldehyde, pH 8.0, 25°C Homo sapiens
0.5337
-
substrate: propionaldehyde, pH 8.0, 25°C Oryctolagus cuniculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-hydroxynonenal + NAD+ + H2O
-
Oryctolagus cuniculus 4-hydroxynonanoate + NADH
-
?
4-hydroxynonenal + NAD+ + H2O
-
Homo sapiens 4-hydroxynonanoate + NADH + H+
-
?
hexanal + NAD+ + H2O
-
Homo sapiens hexanoate + NADH + H+
-
?
hexanal + NAD+ + H2O
-
Oryctolagus cuniculus hexanoate + NADH + H+
-
?
malondialdehyde + NAD+ + H2O
-
Homo sapiens ? + NADH
-
?
malondialdehyde + NAD+ + H2O
-
Oryctolagus cuniculus ? + NADH
-
?
additional information the enzyme may contribute to corneal cellular defense against oxidative damage by metabolizing toxic aldehydes produced during UV-induced lipid peroxidation Homo sapiens ?
-
?
additional information the enzyme may contribute to corneal cellular defense against oxidative damage by metabolizing toxic aldehydes produced during UV-induced lipid peroxidation Oryctolagus cuniculus ?
-
?
propanal + NAD+ + H2O
-
Oryctolagus cuniculus propionate + NADH
-
?

Subunits

Subunits Comment Organism
? x * 54000, SDS-PAGE Homo sapiens
? x * 54000, SDS-PAGE Oryctolagus cuniculus
? x * 54340, calculation from nucleotide sequence Oryctolagus cuniculus

Synonyms

Synonyms Comment Organism
ALDH1A1
-
Homo sapiens
ALDH1A1
-
Oryctolagus cuniculus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens
NAD+
-
Oryctolagus cuniculus