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Literature summary for 1.2.1.3 extracted from

  • Quash, G.; Fournet, G.; Chantepie, J.; Gore, J.; Ardiet, C.; Ardail, D.; Michal, Y.; Reichert, U.
    Novel competitive irreversible inhibitors of aldehyde dehydrogenase (ALDH1): restoration of chemosensitivity of L1210 cells overexpressing ALDH1 and induction of apoptosis in BAF(3) cells overexpressing bcl(2) (2002), Biochem. Pharmacol., 64, 1279-1292.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4-amino-4-methyl-pent-2-ynthioic acid S-methylester i.e. ampal thiolester, inhibits ALDH1 activity in ALDH1-transfected L1210T cells resistant to hydroperoxycyclophosphamide Saccharomyces cerevisiae
4-dimethylamino-4-methyl-pent-2-ynthioic acid S-methylester competitive, 0.4 mM, 30 min, 80% inhibition Saccharomyces cerevisiae
4-methyl-4-morpholin-4-yl-pent-2-ynthioic acid S-methylester 0.6 mM, 60 min, 15% inhibition Saccharomyces cerevisiae
4-tetramethylammonium-4-methyl-pent-2-ynthioic acid S-methylester 0.6 mM, 60 min, 15% inhibition Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
propanal + NAD+ + H2O
-
Saccharomyces cerevisiae propanoate + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
ALDH1
-
Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Saccharomyces cerevisiae

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.28
-
dimethyl ampal thiolester pH 8.5, 37°C Saccharomyces cerevisiae