Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-amino-4-methyl-pent-2-ynthioic acid S-methylester | i.e. ampal thiolester, inhibits ALDH1 activity in ALDH1-transfected L1210T cells resistant to hydroperoxycyclophosphamide | Saccharomyces cerevisiae | |
4-dimethylamino-4-methyl-pent-2-ynthioic acid S-methylester | competitive, 0.4 mM, 30 min, 80% inhibition | Saccharomyces cerevisiae | |
4-methyl-4-morpholin-4-yl-pent-2-ynthioic acid S-methylester | 0.6 mM, 60 min, 15% inhibition | Saccharomyces cerevisiae | |
4-tetramethylammonium-4-methyl-pent-2-ynthioic acid S-methylester | 0.6 mM, 60 min, 15% inhibition | Saccharomyces cerevisiae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
propanal + NAD+ + H2O | - |
Saccharomyces cerevisiae | propanoate + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ALDH1 | - |
Saccharomyces cerevisiae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Saccharomyces cerevisiae |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.28 | - |
dimethyl ampal thiolester | pH 8.5, 37°C | Saccharomyces cerevisiae |