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Literature summary for 1.2.1.3 extracted from

  • Ichihara, K.; Noda, Y.; Tanaka, C.; Kusunose, M.
    Purification of aldehyde dehydrogenase reconstitutively active in fatty alcohol oxidation from rabbit intestinal microsomes (1986), Biochim. Biophys. Acta, 878, 419-425.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
BaCl2 0.1 mM, 10% inhibition of cytosolic enzyme Oryctolagus cuniculus
CsCl2 0.1 mM, 19% inhibition of cytosolic enzyme Oryctolagus cuniculus
Cu2+ 0.1 mM CuSO4, 7% inhibition of microsomal enzyme, 81% inhibition of the cytosolic enzyme Oryctolagus cuniculus
Disulfiram no effect on microsomal enzyme, complete inhibition of the cytosolic enzyme Oryctolagus cuniculus
KCl 0.1 mM, 16% inhibition Oryctolagus cuniculus
Mg2+ 0.1 mM MgCl2, 63% inhibition of cytosolic enzyme Oryctolagus cuniculus
NiCl2 0.1 mM, 24% inhibition of cytosolic enzyme Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.02
-
dodecanal microsomal enzyme Oryctolagus cuniculus
0.035
-
Heptanal microsomal enzyme Oryctolagus cuniculus
0.294
-
propanal microsomal enzyme Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Oryctolagus cuniculus 5829
-
microsome
-
Oryctolagus cuniculus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
BaCl2 0.1 mM, slight activation of microsomal enzyme Oryctolagus cuniculus
CaCl2 0.1 mM, slight activation of microsomal enzyme Oryctolagus cuniculus
CsCl 0.1 mM, slight activation of microsomal enzyme Oryctolagus cuniculus
Mg2+ no effect Oryctolagus cuniculus
NaCl 0.1 mM, slight activation of microsomal enzyme Oryctolagus cuniculus
NiCl2 0.1 mM, slight activation of microsomal enzyme Oryctolagus cuniculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
formation of large aggregates in absence of detergent Oryctolagus cuniculus
60000
-
6 * 60000, SDS-PAGE Oryctolagus cuniculus
370000
-
gel filtration in presence of detergents Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
microsomal enzyme Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
8.75
-
microsomal enzyme Oryctolagus cuniculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetaldehyde + NAD+ + H2O activity with cytosolic enzyme, no activity with microsomal enzyme Oryctolagus cuniculus acetate + NADH + H+
-
?
butanal + NAD+ + H2O n-butanal Oryctolagus cuniculus butyrate + NADH + H+
-
?
decanal + NAD+ + H2O n-decylaldehyde Oryctolagus cuniculus decanoate + NADH
-
?
dodecanal + NAD+ + H2O n-dodecylaldehyde Oryctolagus cuniculus dodecanoate + NADH
-
?
formaldehyde + NAD+ + H2O activity with cytosolic enzyme, no activity with microsomal enzyme Oryctolagus cuniculus formate + NADH
-
?
heptanal + NAD+ + H2O n-heptanal Oryctolagus cuniculus heptanoate + NADH
-
?
hexanal + NAD+ + H2O n-hexanal Oryctolagus cuniculus hexanoate + NADH + H+
-
?
n-nonanal + NAD+ + H2O
-
Oryctolagus cuniculus n-nonanoate + NADH + H+
-
?
octanal + NAD+ + H2O n-octylaldehyde Oryctolagus cuniculus octanoate + NADH
-
?
pentanal + NAD+ + H2O n-pentanal Oryctolagus cuniculus pentanoate + NADH
-
?
propanal + NAD+ + H2O
-
Oryctolagus cuniculus propionate + NADH
-
?

Subunits

Subunits Comment Organism
hexamer 6 * 60000, SDS-PAGE Oryctolagus cuniculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9
-
microsomal enzyme Oryctolagus cuniculus
9.5 10.5 cytosolic enzyme Oryctolagus cuniculus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Oryctolagus cuniculus