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Literature summary for 1.2.1.3 extracted from

  • Klyosov, A.A.
    Kinetics and specificity of human liver aldehyde dehydrogenases toward aliphatic, aromatic, and fused polycyclic aldehydes (1996), Biochemistry, 35, 4457-4467.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2,4-dinitrobenzaldehyde substrate inhibition Homo sapiens
2-naphthaldehyde substrate inhibition Homo sapiens
6-[O-(CH2)5-COOH]-2-naphthaldehyde substrate inhibition Homo sapiens
m-methylbenzaldehyde substrate inhibition Homo sapiens
o-nitrobenzaldehyde substrate inhibition Homo sapiens
p-methylbenzaldehyde substrate inhibition Homo sapiens
p-nitrobenzaldehyde substrate inhibition Homo sapiens
p-nitrocinnamaldehyde substrate inhibition Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0000004
-
5-nitro-1-naphthaldehyde enzyme ALDH-2 Homo sapiens
0.0000004
-
5-bromo-1-naphthaldehyde enzyme ALDH-2 Homo sapiens
0.0000007
-
p-nitrocinnamaldehyde enzyme ALDH-2 Homo sapiens
0.0000023
-
6-(dimethylamino)-2-naphthaldehyde enzyme ALDH-2 Homo sapiens
0.0000025
-
5-bromo-1-naphthaldehyde enzyme ALDH-1 Homo sapiens
0.0000029
-
decanal enzyme form ALDH-1, pH 9.5 Homo sapiens
0.0000032
-
2,4-dinitrobenzaldehyde enzyme ALDH-2 Homo sapiens
0.000004
-
phenanthrene-9-carboxaldehyde enzyme ALDH-2 Homo sapiens
0.000005
-
p-(dimethylamino)cinnamaldehyde enzyme ALDH-2 Homo sapiens
0.0000063
-
o-nitrobenzaldehyde enzyme ALDH-2 Homo sapiens
0.0000063
-
5-(dimethylamino)-2-naphthaldehyde enzyme ALDH-1 Homo sapiens
0.000007
-
p-nitrobenzaldehyde enzyme ALDH-2 Homo sapiens
0.000008
-
2-naphthaldehyde enzyme ALDH-2 Homo sapiens
0.000008
-
propanal major component of enzyme E3 Homo sapiens
0.00001
-
propanal minor component of enzyme E3 Homo sapiens
0.000011
-
5-nitro-1-naphthaldehyde enzyme ALDH-1 Homo sapiens
0.000012
-
octanal enzyme form ALDH-1, pH 9.5 Homo sapiens
0.000017
-
p-methylbenzaldehyde enzyme ALDH-2 Homo sapiens
0.000018
-
benzaldehyde enzyme ALDH-2 Homo sapiens
0.000018
-
p-Methoxybenzaldehyde enzyme ALDH-2 Homo sapiens
0.000018
-
m-methylbenzaldehyde enzyme ALDH-2 Homo sapiens
0.000018
-
Heptanal enzyme form ALDH-1, pH 9.5 Homo sapiens
0.00002
-
p-(dimethylamino)-benzaldehyde enzyme ALDH-2 Homo sapiens
0.000022
-
decanal enzyme form ALDH-2, pH 9.5 Homo sapiens
0.000027
-
Heptanal enzyme form ALDH-2, pH 9.5 Homo sapiens
0.000028
-
octanal enzyme form ALDH-2, pH 9.5 Homo sapiens
0.000029
-
phenylacetaldehyde enzyme ALDH-2 Homo sapiens
0.00003
-
hexanal enzyme form ALDH-2, pH 9.5 Homo sapiens
0.000034
-
pentanal enzyme form ALDH-2, pH 9.5 Homo sapiens
0.000035
-
trans-cinnamaldehyde enzyme ALDH-2 Homo sapiens
0.00004
-
propanal minor component of enzyme E3 Homo sapiens
0.000041
-
hexanal enzyme form ALDH-1, pH 9.5 Homo sapiens
0.00005
-
acetaldehyde major component of enzyme E3 Homo sapiens
0.000054
-
fluorene-2-carboxaldehyde enzyme ALDH-1 Homo sapiens
0.00006
-
7-acetoxycoumarin-3-carboxaldehyde enzyme ALDH-2 Homo sapiens
0.00006
-
p-(dimethylamino)benzaldehyde enzyme ALDH-1 Homo sapiens
0.000062
-
7-(dimethylamino)-coumarin-3-carboxaldehyde enzyme ALDH-2 Homo sapiens
0.000065
-
4-methoxy-1-naphthaldehyde enzyme ALDH-2 Homo sapiens
0.00009
-
m-methoxybenzaldehyde enzyme ALDH-2 Homo sapiens
0.000095
-
propanal enzyme form ALDH-2, pH 9.5 Homo sapiens
0.00015
-
Indole-3-acetaldehyde enzyme ALDH-2 Homo sapiens
0.00016
-
pentanal enzyme form ALDH-1, pH 9.5 Homo sapiens
0.0002
-
4-methyoxy-1-naphthaldehyde enzyme ALDH-1 Homo sapiens
0.00028
-
7-methoxycoumarin-3-carboxaldehyde enzyme ALDH-2 Homo sapiens
0.00031
-
Indole-3-acetaldehyde enzyme ALDH-1 Homo sapiens
0.00033
-
3,4-dimethoxybenzaldehyde enzyme ALDH-2 Homo sapiens
0.00033
-
quinoline-3-carboxaldehyde enzyme ALDH-2 Homo sapiens
0.0004
-
trans-cinnamaldehyde enzyme ALDH-1 Homo sapiens
0.0005
-
hydrocinnamaldehyde enzyme ALDH-2 Homo sapiens
0.00069
-
6,7-dimethoxycoumarin-3-carboxaldehyde enzyme ALDH-2 Homo sapiens
0.0007
-
propanal enzyme form ALDH-1, pH 9.5 Homo sapiens
0.0008
-
o-methoxybenzaldehyde enzyme ALDH-2 Homo sapiens
0.0009
-
p-(dimethylamino)cinnamaldehyde enzyme ALDH-1 Homo sapiens
0.00093
-
alpha-phenylpropanal enzyme ALDH-2 Homo sapiens
0.00142
-
p-(dimethylamino)cinnamaldehyde enzyme ALDH-1 Homo sapiens
0.00196
-
3-Pyridinecarboxaldehyde enzyme ALDH-2 Homo sapiens
0.00213
-
7-(dimethylamino)-2-quinolinone-4-carboxaldehyde enzyme ALDH-2 Homo sapiens
0.0028
-
quinoline-4-carboxaldehyde enzyme ALDH-2 Homo sapiens
0.0045
-
propanal enzyme form ALDH-1, pH 9.5 Homo sapiens
0.0054
-
6-methoxy-2-quinolinone-4-carboxaldehyde enzyme ALDH-2 Homo sapiens
0.0055
-
phenylacetaldehyde enzyme ALDH-1 Homo sapiens
0.01 0.02 Indole-3-aldehyde enzyme ALDH-2 Homo sapiens
0.0189
-
5-methoxyindole-3-carboxaldehyde enzyme ALDH-2 Homo sapiens
0.05
-
7-methoxy-2-quinolinone-4-carboxaldehyde enzyme ALDH-2 Homo sapiens
0.15
-
7-hydroxycoumarin-3-carboxaldehyde enzyme ALDH-2 Homo sapiens
0.18
-
acetaldehyde enzyme form ALDH-1, pH 9.5 Homo sapiens
0.32
-
formaldehyde enzyme ALDH-2 Homo sapiens
1.3
-
o-methylbenzaldehyde enzyme ALDH-2 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion enzyme ALDH-2 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,4-dinitrobenzaldehyde + NAD+ + H2O
-
Homo sapiens 2,4-dinitrobenzoate + NADH
-
?
2-naphthaldehyde + NAD+ + H2O
-
Homo sapiens 2-naphthoate + NADH
-
?
2-quinolinone-4-carboxaldehyde + NAD+ + H2O
-
Homo sapiens 2-quinolinone-4-carboxylate + NADH
-
?
3,4-dimethoxybenzaldehyde + NAD+ + H2O
-
Homo sapiens 3,4-dimethoxybenzoate + NADH
-
?
3-pyridinecarboxaldehyde + NAD+ + H2O
-
Homo sapiens 3-pyridinecarboxylate + NADH
-
?
4-methoxy-1-naphthaldehyde + NAD+ + H2O
-
Homo sapiens 4-methoxy-1-naphthoate + NADH
-
?
4-nitro-1-naphthaldehyde + NAD+ + H2O
-
Homo sapiens 4-nitro-1-naphthoate + NADH
-
?
5-(dimethylamino)-2-naphthaldehyde + NAD+ + H2O
-
Homo sapiens 5-(dimethylamino)-2-naphthoate + NADH + H+
-
r
5-bromo-1-naphthaldehyde + NAD+ + H2O
-
Homo sapiens 5-bromo-1-naphthoate + NADH
-
?
5-methoxyindole-3-carboxaldehyde + NAD+ + H2O
-
Homo sapiens 5-methoxyindole-3-carboxylate + NADH
-
?
5-nitro-1-naphthaldehyde + NAD+ + H2O
-
Homo sapiens 5-nitro-1-naphthoate + NADH + H+
-
r
6,7-dimethoxycoumarin-3-carboxaldehyde + NAD+ + H2O
-
Homo sapiens 6,7-dimethoxycoumarin-3-carboxylate + NADH + H+
-
r
6,7-dimethoxycoumarin-4-carboxaldehyde + NAD+ + H2O
-
Homo sapiens 6,7-dimethoxycoumarin-4-carboxylate + NADH
-
?
6-(dimethylamino)-2-naphthaldehyde + NAD+ + H2O
-
Homo sapiens 6-(dimethylamino)-2-naphthoate + NADH
-
?
6-methoxy-2-quinolinone-4-carboxaldehyde + NAD+ + H2O
-
Homo sapiens 6-methoxy-2-quinolinone-4-carboxylate + NADH
-
?
7-(dimethylamino)-2-quinolinone-4-carboxaldehyde + NAD+ + H2O
-
Homo sapiens 7-(dimethylamino)-2-quinolinone-4-carboxylate + NADH
-
?
7-(dimethylamino)-coumarin-3-carboxaldehyde + NAD+ + H2O
-
Homo sapiens 7-(dimethylamino)-coumarin-3-carboxylate + NADH + H+
-
r
7-(dimethylamino)coumarin-4-carboxaldehyde + NAD+ + H2O
-
Homo sapiens 7-(dimethylamino)coumarin-4-carboxylate + NADH
-
?
7-acetoxycoumarin-3-carboxaldehyde + NAD+ + H2O
-
Homo sapiens 7-acetoxycoumarin-3-carboxylate + NADH + H+
-
r
7-acetoxycoumarin-4-carboxaldehyde + NAD+ + H2O
-
Homo sapiens 7-acetoxycoumarin-4-carboxylate + NADH
-
?
7-hydroxycoumarin-3-carboxaldehyde + NAD+ + H2O
-
Homo sapiens 7-hydroxycoumarin-3-carboxylate + NADH + H+
-
r
7-hydroxycoumarin-4-carboxaldehyde + NAD+ + H2O
-
Homo sapiens 7-hydroxycoumarin-4-carboxylate + NADH
-
?
7-methoxy-2-quinolinone-4-carboxaldehyde + NAD+ + H2O
-
Homo sapiens 7-methoxy-2-quinolinone-4-carboxylate + NADH
-
?
7-methoxycoumarin-3-carboxaldehyde + NAD+ + H2O
-
Homo sapiens 7-methoxycoumarin-3-carboxylate + NADH + H+
-
r
7-methoxycoumarin-4-carboxaldehyde + NAD+ + H2O
-
Homo sapiens 7-methoxycoumarin-4-carboxylate + NADH
-
?
acetaldehyde + NAD+ + H2O
-
Homo sapiens acetate + NADH + H+
-
?
alpha-phenylpropanal + NAD+ + H2O
-
Homo sapiens alpha-phenylpropionate + NADH
-
?
benzaldehyde + NAD+ + H2O
-
Homo sapiens benzoate + NADH + H+
-
?
decanal + NAD+ + H2O
-
Homo sapiens decanoate + NADH
-
?
fluorene-2-carboxaldehyde + NAD+ + H2O
-
Homo sapiens fluorene-2-carboxylate + NADH
-
?
formaldehyde + NAD+ + H2O activity with enzyme ALDH-2, no activity with enzyme ALDH-1 Homo sapiens formate + NADH
-
?
heptanal + NAD+ + H2O
-
Homo sapiens heptanoate + NADH
-
?
hexanal + NAD+ + H2O
-
Homo sapiens hexanoate + NADH + H+
-
?
hydrocinnamaldehyde + NAD+ + H2O
-
Homo sapiens hydrocinnamate + NADH
-
?
indole-3-acetaldehyde + NAD+ + H2O
-
Homo sapiens indole-3-acetate + NADH + H+
-
?
indole-3-aldehyde + NAD+ + H2O
-
Homo sapiens indole-3-carboxylate + NADH
-
?
m-hydroxybenzaldehyde + NAD+ + H2O
-
Homo sapiens m-hydroxybenzoate + NADH + H+
-
?
m-methoxybenzaldehyde + NAD+ + H2O
-
Homo sapiens m-methoxybenzoate + NADH + H+
-
?
m-methylbenzaldehyde + NAD+ + H2O
-
Homo sapiens m-methylbenzoate + NADH
-
?
o-hydroxybenzaldehyde + NAD+ + H2O
-
Homo sapiens o-hydroxybenzoate + NADH + H+
-
?
o-methoxybenzaldehyde + NAD+ + H2O
-
Homo sapiens o-methoxybenzoate + NADH + H+
-
?
o-methylbenzaldehyde + NAD+ + H2O
-
Homo sapiens o-methylbenzoate + NADH
-
?
o-nitrobenzaldehyde + NAD+ + H2O
-
Homo sapiens o-nitrobenzoate + NADH
-
?
octanal + NAD+ + H2O
-
Homo sapiens octanoate + NADH
-
?
p-(dimethylamino)-benzaldehyde + NAD+ + H2O
-
Homo sapiens p-(dimethylamino)benzoate + NADH
-
?
p-(dimethylamino)cinnamaldehyde + NAD+ + H2O
-
Homo sapiens p-(dimethylamino)cinnamate + NADH
-
?
p-methoxybenzaldehyde + NAD+ + H2O
-
Homo sapiens p-methoxybenzoate + NADH + H+
-
?
p-methylbenzaldehyde + NAD+ + H2O
-
Homo sapiens p-methylbenzoate + NADH
-
?
p-nitrobenzaldehyde + NAD+ + H2O
-
Homo sapiens p-nitrobenzoate + NADH
-
?
p-nitrocinnamaldehyde + NAD+ + H2O
-
Homo sapiens p-nitrocinnamate + NADH
-
?
pentanal + NAD+ + H2O
-
Homo sapiens pentanoate + NADH
-
?
phenanthrene-9-carboxaldehyde + NAD+ + H2O
-
Homo sapiens phenanthrene-9-carboxylate + NADH
-
?
phenylacetaldehyde + NAD+ + H2O
-
Homo sapiens phenylacetate + NADH + H+
-
?
propanal + NAD+ + H2O
-
Homo sapiens propionate + NADH
-
?
quinoline-3-carboxaldehyde + NAD+ + H2O
-
Homo sapiens quinoline-3-carboxylate + NADH
-
?
quinoline-4-carboxaldehyde + NAD+ + H2O
-
Homo sapiens quinoline-4-carboxylate + NADH
-
?
trans-cinnamaldehyde + NAD+ + H2O
-
Homo sapiens trans-cinnamate + NADH
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.158
-
5-bromo-1-naphthaldehyde enzyme ALDH-1 Homo sapiens
0.25
-
5-bromo-1-naphthaldehyde enzyme ALDH-2 Homo sapiens
0.3
-
phenanthrene-9-carboxaldehyde enzyme ALDH-2 Homo sapiens
0.367
-
o-methoxybenzaldehyde enzyme ALDH-2 Homo sapiens
0.45
-
p-nitrocinnamaldehyde enzyme ALDH-2 Homo sapiens
0.55
-
5-nitro-1-naphthaldehyde enzyme ALDH-1 Homo sapiens
0.617
-
6-(dimethylamino)-2-naphthaldehyde enzyme ALDH-2 Homo sapiens
0.667
-
2,4-dinitrobenzaldehyde enzyme ALDH-2 Homo sapiens
0.833
-
5-nitro-1-naphthaldehyde enzyme ALDH-2 Homo sapiens
0.983
-
6,7-dimethoxycoumarin-3-carboxaldehyde enzyme ALDH-2 Homo sapiens
0.983
-
6-methoxy-2-quinolinone-4-carboxaldehyde enzyme ALDH-2 Homo sapiens
1
-
m-hydroxybenzaldehyde enzyme ALDH-2 Homo sapiens
1.08
-
7-acetoxycoumarin-3-carboxaldehyde enzyme ALDH-2 Homo sapiens
1.23
-
o-nitrobenzaldehyde enzyme ALDH-2 Homo sapiens
1.3
-
7-(dimethylamino)-coumarin-3-carboxaldehyde enzyme ALDH-2 Homo sapiens
1.42
-
3,4-dimethoxybenzaldehyde enzyme ALDH-2 Homo sapiens
1.5
-
p-(dimethylamino)cinnamaldehyde enzyme ALDH-2 Homo sapiens
1.57
-
2-quinolinone-4-carboxaldehyde enzyme ALDH-2 Homo sapiens
2.13
-
p-(dimethylamino)benzaldehyde enzyme ALDH-1 Homo sapiens
2.17
-
7-(dimethylamino)-2-quinolinone-4-carboxaldehyde enzyme ALDH-2 Homo sapiens
2.33
-
p-(dimethylamino)-benzaldehyde enzyme ALDH-2 Homo sapiens
2.5
-
trans-cinnamaldehyde enzyme ALDH-2 Homo sapiens
2.5
-
p-Methoxybenzaldehyde enzyme ALDH-2 Homo sapiens
2.67
-
5-(dimethylamino)-2-naphthaldehyde enzyme ALDH-1 Homo sapiens
2.75
-
o-methylbenzaldehyde enzyme ALDH-2 Homo sapiens
2.83
-
fluorene-2-carboxaldehyde enzyme ALDH-2 Homo sapiens
3
-
p-methylbenzaldehyde enzyme ALDH-2 Homo sapiens
3.17
-
7-methoxycoumarin-3-carboxaldehyde enzyme ALDH-2 Homo sapiens
3.83
-
decanal enzyme form ALDH-1, pH 9.5 Homo sapiens
4
-
2-naphthaldehyde enzyme ALDH-2 Homo sapiens
4.17
-
hexanal enzyme form ALDH-1, pH 9.5 Homo sapiens
4.17
-
octanal enzyme form ALDH-2, pH 9.5 Homo sapiens
4.33
-
Heptanal enzyme form ALDH-1, pH 9.5 Homo sapiens
4.42
-
4-methoxy-1-naphthaldehyde enzyme ALDH-1 Homo sapiens
4.5
-
m-methylbenzaldehyde enzyme ALDH-2 Homo sapiens
4.67
-
quinoline-4-carboxaldehyde enzyme ALDH-2 Homo sapiens
5.33
-
7-methoxy-2-quinolinone-4-carboxaldehyde enzyme ALDH-2 Homo sapiens
5.83
-
benzaldehyde enzyme ALDH-2 Homo sapiens
5.83
-
m-methoxybenzaldehyde enzyme ALDH-2 Homo sapiens
6
-
fluorene-2-carboxaldehyde enzyme ALDH-1 Homo sapiens
7.17
-
p-nitrobenzaldehyde enzyme ALDH-2 Homo sapiens
7.83
-
trans-cinnamaldehyde enzyme ALDH-1 Homo sapiens
7.9
-
7-(dimethylamino)coumarin-4-carboxaldehyde enzyme ALDH-2 Homo sapiens
8.17
-
p-(dimethylamino)cinnamaldehyde enzyme ALDH-1 Homo sapiens
8.17
-
pentanal enzyme form ALDH-1, pH 9.5 Homo sapiens
8.33
-
7-hydroxycoumarin-3-carboxaldehyde enzyme ALDH-2 Homo sapiens
9.33
-
Indole-3-acetaldehyde enzyme ALDH-2 Homo sapiens
11.2
-
quinoline-3-carboxaldehyde enzyme ALDH-2 Homo sapiens
11.3
-
Indole-3-acetaldehyde enzyme ALDH-1 Homo sapiens
11.7
-
decanal enzyme form ALDH-2, pH 9.5 Homo sapiens
12.3
-
hydrocinnamaldehyde enzyme ALDH-2 Homo sapiens
13.2
-
acetaldehyde enzyme form ALDH-1, pH 9.5 Homo sapiens
15
-
octanal enzyme form ALDH-2, pH 9.5 Homo sapiens
15.2
-
alpha-phenylpropanal enzyme ALDH-2 Homo sapiens
19.7
-
acetaldehyde enzyme form ALDH-2, pH 9.5 Homo sapiens
19.7
-
propanal enzyme form ALDH-2 Homo sapiens
22.7
-
Heptanal enzyme form ALDH-2, pH 9.5 Homo sapiens
22.8
-
pentanal enzyme form ALDH-2, pH 9.5 Homo sapiens
27.7
-
3-Pyridinecarboxaldehyde enzyme ALDH-2 Homo sapiens
28.5
-
hexanal enzyme form ALDH-2, pH 9.5 Homo sapiens
30
-
phenylacetaldehyde enzyme ALDH-2 Homo sapiens
50
-
phenylacetaldehyde enzyme ALDH-1 Homo sapiens
67.5
-
formaldehyde enzyme ALDH-2 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens