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Literature summary for 1.2.1.27 extracted from

  • Kedishvili, N.Y.; Goodwin, G.W.; Popov, K.M.; Harris, R.A.
    Mammalian methylmalonate-semialdehyde dehydrogenase (2000), Methods Enzymol., 324, 207-218.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
-
Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
C285A expressed in Escherichia coli, no activity Rattus norvegicus
N251E expressed in Escherichia coli, no activity Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0025
-
2-Methyl-3-oxopropanoate
-
Rattus norvegicus
0.0045
-
malonate semialdehyde
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion mitochondrial targeting sequence Rattus norvegicus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
55330
-
4 * 55330, cDNA sequence Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
side-chain modification acylation of active site cysteine residue Cys-285 by long-chain fatty acyl-CoA esters inactivates the enzyme Rattus norvegicus

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-methyl-3-oxopropanoate + CoA + NAD+
-
Rattus norvegicus propanoyl-CoA + CO2 + NADH
-
ir
malonate semialdehyde + CoA + NAD+
-
Rattus norvegicus acetyl-CoA + CO2 + NADH
-
?
p-nitrophenyl acetate + CoA + NAD+
-
Rattus norvegicus p-nitrophenol + acetyl-CoA + NADH
-
ir

Subunits

Subunits Comment Organism
tetramer 4 * 55330, cDNA sequence Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
CoA
-
Homo sapiens
CoA
-
Rattus norvegicus
NAD+
-
Homo sapiens
NAD+
-
Rattus norvegicus