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Literature summary for 1.2.1.24 extracted from

  • Langendorf, C.G.; Key, T.L.; Fenalti, G.; Kan, W.T.; Buckle, A.M.; Caradoc-Davies, T.; Tuck, K.L.; Law, R.H.; Whisstock, J.C.
    The X-ray crystal structure of Escherichia coli succinic semialdehyde dehydrogenase; structural insights into NADP+/enzyme interactions (2010), PLoS One, 5, e9280.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
A237S the mutant shows 65% activity compared to the wild type enzyme Homo sapiens
C223Y the mutant shows 5% activity compared to the wild type enzyme Homo sapiens
C93F the mutant shows 3% activity compared to the wild type enzyme Homo sapiens
G176R the mutant shows less than 1% activity compared to the wild type enzyme Homo sapiens
G268E the mutant shows less than 1% activity compared to the wild type enzyme Homo sapiens
G409D the mutant shows less than 1% activity compared to the wild type enzyme Homo sapiens
G46R the mutant shows 87% activity compared to the wild type enzyme Homo sapiens
G533R the mutant shows less than 1% activity compared to the wild type enzyme Homo sapiens
H180Y the mutant shows 83% activity compared to the wild type enzyme Homo sapiens
N255S the mutant shows 17% activity compared to the wild type enzyme Homo sapiens
N335K the mutant shows 1% activity compared to the wild type enzyme Homo sapiens
P182L the mutant shows 48% activity compared to the wild type enzyme Homo sapiens
P382L the mutant shows 2% activity compared to the wild type enzyme Homo sapiens
T233M the mutant shows 4% activity compared to the wild type enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
succinate semialdehyde + NAD+ + H2O Homo sapiens
-
succinate + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P51649
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
succinate semialdehyde + NAD+ + H2O
-
Homo sapiens succinate + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
SSADH
-
Homo sapiens
succinic semialdehyde dehydrogenase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens

General Information

General Information Comment Organism
metabolism SSADH plays an essential role in the metabolism of the inhibitory neurotransmitter c-aminobutyric acid Homo sapiens