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Literature summary for 1.2.1.16 extracted from

  • Jang, E.H.; Lim, J.E.; Chi, Y.M.; Lee, K.S.
    Crystallization and preliminary X-ray crystallographic studies of succinic semialdehyde dehydrogenase from Streptococcus pyogenes (2012), Acta Crystallogr. Sect. F, 68, 288-291.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.2.1.16

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 (DE3) cells Streptococcus pyogenes

Crystallization (Commentary)

Crystallization (Comment) Organism
apoenzyme and in complex with NAD+, hanging drop vapor diffusion method, using 0.1 M MES monohydrate pH 5.8-6.1 and 18-23% (w/v) polyethylene glycol 4000 Streptococcus pyogenes

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
52000
-
 2 * 52000, SDS-PAGE Streptococcus pyogenes

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
succinate semialdehyde + NAD+ + H2O Streptococcus pyogenes
-
 succinate + NADH + H+
-
 ?
succinate semialdehyde + NADP+ + H2O Streptococcus pyogenes
-
 succinate + NADPH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Streptococcus pyogenes
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
succinate semialdehyde + NAD+ + H2O
-
 Streptococcus pyogenes succinate + NADH + H+
-
 ?
succinate semialdehyde + NADP+ + H2O
-
 Streptococcus pyogenes succinate + NADPH + H+
-
 ?

Subunits

Subunits Comment Organism
homodimer 2 * 52000, SDS-PAGE Streptococcus pyogenes

Synonyms

Synonyms Comment Organism
NAD+/NADP+-dependent SSADH
-
 Streptococcus pyogenes
SSADH
-
 Streptococcus pyogenes
succinic semialdehyde dehydrogenase
-
 Streptococcus pyogenes

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Streptococcus pyogenes
NADP+
-
 Streptococcus pyogenes