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Literature summary for 1.2.1.16 extracted from

  • Lutke-Eversloh, T.; Steinbuchel, A.
    Biochemical and molecular characterization of a succinate semialdehyde dehydrogenase involved in the catabolism of 4-hydroxybutyric acid in Ralstonia eutropha (1999), FEMS Microbiol. Lett., 181, 63-71.
    View publication on PubMed
Search for more literature for 1.2.1.16

Cloned(Commentary)

Cloned (Comment) Organism
gabD gene cloned, expression in Escherichia coli Cupriavidus necator

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
succinate semialdehyde + NADP+ + H2O Cupriavidus necator involved in the degradation of gamma-aminobutyrate succinate + NADPH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Cupriavidus necator Q9RBF6
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Cupriavidus necator
0.0038
-
 H16-strain, coenzyme NAD+ Cupriavidus necator
0.0097
-
 SK4580-strain, coenzyme NAD+ Cupriavidus necator
0.0105
-
 HF39-strain, coenzyme NAD+ Cupriavidus necator
0.0172
-
 SHF3-strain, coenzyme NAD+ Cupriavidus necator
0.0235
-
 SK4580-strain, coenzyme NADP+ Cupriavidus necator
0.0253
-
 H16-strain, coenzyme NADP+ Cupriavidus necator
0.0319
-
 SK4575-strain, coenzyme NAD+ Cupriavidus necator
0.0355
-
 SK4575-strain, coenzyme NADP+ Cupriavidus necator
0.0409
-
 HF39-strain, coenzyme NADP+ Cupriavidus necator
0.0457
-
 SHF3-strain, coenzyme NADP+ Cupriavidus necator

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
succinate semialdehyde + NADP+ + H2O
-
 Cupriavidus necator succinate + NADPH + H+
-
 ?
succinate semialdehyde + NADP+ + H2O involved in the degradation of gamma-aminobutyrate Cupriavidus necator succinate + NADPH + H+
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
31
-
-
 Cupriavidus necator

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
50
-
 10 min incubation, stable up to Cupriavidus necator

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
11
-
 in 50 mM glycine-NaOH buffer Cupriavidus necator

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Cupriavidus necator
NADP+
-
 Cupriavidus necator