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Literature summary for 1.2.1.16 extracted from

  • Donelly, M.I.; Cooper, R.A.
    Succinic semialdehyde dehydrogenases of Escherichia coli: their role in the degradation of p-hydroxyphenylacetate and gamma-aminobutyrate (1981), Eur. J. Biochem., 113, 555-561.
    View publication on PubMed
Search for more literature for 1.2.1.16

Activating Compound

Activating Compound Comment Organism Structure
4-aminobutyric acid induction Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
200000
-
 gel filtration Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
succinate semialdehyde + NADP+ + H2O Escherichia coli involved in the degradation of gamma-aminobutyrate succinate + NADPH + H+
-
 ?
succinate semialdehyde + NADP+ + H2O Escherichia coli implicated in 4-hydroxyphenylacetic acid and gamma-aminobutyric acid catabolism succinate + NADPH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 wild type strain B and mutant able to grow on gamma-aminobutyrate as sole C- and N-source
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.021
-
 wild type, succinate used as C-source, gamma-aminobutyrate and NH3 used as N-source Escherichia coli
0.023
-
 wild type, succinate used as C-source and proline used as N-source Escherichia coli
0.026
-
 wild type, succinate used as C-source and NH3 used as N-source Escherichia coli
0.034
-
 wild type, 4-hydroxyphenylacetate used as C-source and NH3 used as N-source Escherichia coli
0.089
-
 mutant, glucose used as C-source and NH3 used as N-source Escherichia coli
0.097
-
 mutant, succinate used as C-source and NH3 used as N-source Escherichia coli
0.105
-
 wild type, succinate used as C-source and gamma-aminobutyrate used as N-source Escherichia coli
0.319
-
 mutant, gamma-aminobutyrate used as C-source and NH3 used as N-source Escherichia coli
0.351
-
 mutant, succinate used as C-source and gamma-aminobutyrate used as N-source Escherichia coli
0.395
-
 mutant, glucose used as C-source and gamma-aminobutyrate used as N-source Escherichia coli
0.408
-
 mutant, gamma-aminobutyrate used as C-source and as N-source Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
succinate semialdehyde + NADP+ + H2O
-
 Escherichia coli succinate + NADPH + H+
-
 ?
succinate semialdehyde + NADP+ + H2O involved in the degradation of gamma-aminobutyrate Escherichia coli succinate + NADPH + H+
-
 ?
succinate semialdehyde + NADP+ + H2O implicated in 4-hydroxyphenylacetic acid and gamma-aminobutyric acid catabolism Escherichia coli succinate + NADPH + H+
-
 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
50
-
 75% activity after 2 min Escherichia coli

Cofactor

Cofactor Comment Organism Structure
NADP+ specific for Escherichia coli