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Literature summary for 1.2.1.11 extracted from

  • Dahal, G.P.; Launder, D.; McKeone, K.M.M.; Hunter, J.P.; Conti, H.R.; Viola, R.E.
    Aspartate semialdehyde dehydrogenase inhibition suppresses the growth of the pathogenic fungus Candida albicans (2020), Drug Dev. Res., 81, 736-744 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,4-Naphthoquinone
-
Candida albicans
1-amino-2-naphthol-4-sulfonic acid
-
Candida albicans
2,3-dichloro-1,4-naphthoquinone
-
Candida albicans
2,3-dichloro-5,6-dicyano-1,4-benzoquinone
-
Candida albicans
2,3-dichloro-5,8-dihydroxy-1,4-naphthoquinone
-
Candida albicans
2-bromo-1,4-naphthoquinone
-
Candida albicans
2-Chloro-1,4-naphthoquinone
-
Candida albicans
5-aminoisoquinoline
-
Candida albicans
catechol
-
Candida albicans
cyclohexyl iodide
-
Candida albicans
additional information cytotoxicity analysis of inhibitors against Candida albicans cells, overview Candida albicans
naphthalene-2,3-dialdehyde
-
Candida albicans
p-benzoquinone
-
Candida albicans
p-hydroquinone
-
Candida albicans
phthalaldehyde
-
Candida albicans
tetrachloro-1,4-benzoquinone
-
Candida albicans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-aspartate 4-semialdehyde + phosphate + NADP+ Candida albicans
-
L-4-aspartyl phosphate + NADPH + H+
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+ Candida albicans CAF2-1
-
L-4-aspartyl phosphate + NADPH + H+
-
r

Organism

Organism UniProt Comment Textmining
Candida albicans
-
-
-
Candida albicans CAF2-1
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-aspartate 4-semialdehyde + phosphate + NADP+
-
Candida albicans L-4-aspartyl phosphate + NADPH + H+
-
r
L-aspartate 4-semialdehyde + phosphate + NADP+
-
Candida albicans CAF2-1 L-4-aspartyl phosphate + NADPH + H+
-
r

Synonyms

Synonyms Comment Organism
ASADH
-
Candida albicans
aspartate semialdehyde dehydrogenase
-
Candida albicans

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Candida albicans
NADPH
-
Candida albicans

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00065
-
2,3-dichloro-1,4-naphthoquinone pH and temperature not specified in the publication Candida albicans
0.0041
-
2-Chloro-1,4-naphthoquinone pH and temperature not specified in the publication Candida albicans
0.0061
-
2-bromo-1,4-naphthoquinone pH and temperature not specified in the publication Candida albicans
0.0115
-
2,3-dichloro-5,8-dihydroxy-1,4-naphthoquinone pH and temperature not specified in the publication Candida albicans
0.045
-
naphthalene-2,3-dialdehyde pH and temperature not specified in the publication Candida albicans
0.0576
-
2,3-dichloro-5,6-dicyano-1,4-benzoquinone pH and temperature not specified in the publication Candida albicans
0.062
-
1,4-Naphthoquinone pH and temperature not specified in the publication Candida albicans
0.063
-
phthalaldehyde pH and temperature not specified in the publication Candida albicans
0.065
-
p-hydroquinone pH and temperature not specified in the publication Candida albicans
0.066
-
tetrachloro-1,4-benzoquinone pH and temperature not specified in the publication Candida albicans
0.073
-
p-benzoquinone pH and temperature not specified in the publication Candida albicans
0.084
-
5-aminoisoquinoline pH and temperature not specified in the publication Candida albicans
0.093
-
1-amino-2-naphthol-4-sulfonic acid pH and temperature not specified in the publication Candida albicans
0.121
-
catechol pH and temperature not specified in the publication Candida albicans
0.154
-
cyclohexyl iodide pH and temperature not specified in the publication Candida albicans