Protein Variants | Comment | Organism |
---|---|---|
C136S | the mutation virtually eliminates catalysis | Haemophilus influenzae |
E243D | the mutant shows 1.2% activity compared to the wild type enzyme | Haemophilus influenzae |
H277N | the mutant shows 1% activity compared to the wild type enzyme | Haemophilus influenzae |
K246R | the mutant shows 3.3% activity compared to the wild type enzyme | Haemophilus influenzae |
R103K | the mutant shows 0.4% activity compared to the wild type enzyme | Haemophilus influenzae |
R103L | the mutant shows 0.07% activity compared to the wild type enzyme | Haemophilus influenzae |
R267L | the mutant shows 9.5% activity compared to the wild type enzyme | Haemophilus influenzae |
R270K | the mutant shows 0.1% activity compared to the wild type enzyme | Haemophilus influenzae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-4-aspartyl phosphate + NADPH + H+ | Escherichia coli | - |
L-aspartate 4-semialdehyde + phosphate + NADP+ | - |
r | |
L-4-aspartyl phosphate + NADPH + H+ | Streptococcus pneumoniae | - |
L-aspartate 4-semialdehyde + phosphate + NADP+ | - |
r | |
L-4-aspartyl phosphate + NADPH + H+ | Candida albicans | - |
L-aspartate 4-semialdehyde + phosphate + NADP+ | - |
r | |
L-4-aspartyl phosphate + NADPH + H+ | Methanocaldococcus jannaschii | - |
L-aspartate 4-semialdehyde + phosphate + NADP+ | - |
r | |
L-4-aspartyl phosphate + NADPH + H+ | Haemophilus influenzae | - |
L-aspartate 4-semialdehyde + phosphate + NADP+ | - |
r | |
L-4-aspartyl phosphate + NADPH + H+ | Vibrio cholerae | - |
L-aspartate 4-semialdehyde + phosphate + NADP+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Candida albicans | - |
- |
- |
Escherichia coli | - |
- |
- |
Haemophilus influenzae | P44801 | - |
- |
Methanocaldococcus jannaschii | - |
- |
- |
Streptococcus pneumoniae | - |
- |
- |
Vibrio cholerae | Q9KQG2 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-4-aspartyl phosphate + NADPH + H+ | - |
Escherichia coli | L-aspartate 4-semialdehyde + phosphate + NADP+ | - |
r | |
L-4-aspartyl phosphate + NADPH + H+ | - |
Streptococcus pneumoniae | L-aspartate 4-semialdehyde + phosphate + NADP+ | - |
r | |
L-4-aspartyl phosphate + NADPH + H+ | - |
Candida albicans | L-aspartate 4-semialdehyde + phosphate + NADP+ | - |
r | |
L-4-aspartyl phosphate + NADPH + H+ | - |
Methanocaldococcus jannaschii | L-aspartate 4-semialdehyde + phosphate + NADP+ | - |
r | |
L-4-aspartyl phosphate + NADPH + H+ | - |
Haemophilus influenzae | L-aspartate 4-semialdehyde + phosphate + NADP+ | - |
r | |
L-4-aspartyl phosphate + NADPH + H+ | - |
Vibrio cholerae | L-aspartate 4-semialdehyde + phosphate + NADP+ | - |
r | |
L-aspartate 4-semialdehyde + phosphate + NADP+ | - |
Escherichia coli | L-4-aspartyl phosphate + NADPH + H+ | - |
r | |
L-aspartate 4-semialdehyde + phosphate + NADP+ | - |
Streptococcus pneumoniae | L-4-aspartyl phosphate + NADPH + H+ | - |
r | |
L-aspartate 4-semialdehyde + phosphate + NADP+ | - |
Candida albicans | L-4-aspartyl phosphate + NADPH + H+ | - |
r | |
L-aspartate 4-semialdehyde + phosphate + NADP+ | - |
Methanocaldococcus jannaschii | L-4-aspartyl phosphate + NADPH + H+ | - |
r | |
L-aspartate 4-semialdehyde + phosphate + NADP+ | - |
Haemophilus influenzae | L-4-aspartyl phosphate + NADPH + H+ | - |
r | |
L-aspartate 4-semialdehyde + phosphate + NADP+ | - |
Vibrio cholerae | L-4-aspartyl phosphate + NADPH + H+ | - |
r |
Subunits | Comment | Organism |
---|---|---|
homodimer | - |
Escherichia coli |
homodimer | - |
Streptococcus pneumoniae |
homodimer | - |
Candida albicans |
homodimer | - |
Methanocaldococcus jannaschii |
homodimer | - |
Haemophilus influenzae |
homodimer | - |
Vibrio cholerae |
Synonyms | Comment | Organism |
---|---|---|
ASADH | - |
Escherichia coli |
ASADH | - |
Streptococcus pneumoniae |
ASADH | - |
Candida albicans |
ASADH | - |
Methanocaldococcus jannaschii |
ASADH | - |
Haemophilus influenzae |
ASADH | - |
Vibrio cholerae |
aspartate-beta-semialdehyde dehydrogenase | - |
Escherichia coli |
aspartate-beta-semialdehyde dehydrogenase | - |
Streptococcus pneumoniae |
aspartate-beta-semialdehyde dehydrogenase | - |
Candida albicans |
aspartate-beta-semialdehyde dehydrogenase | - |
Methanocaldococcus jannaschii |
aspartate-beta-semialdehyde dehydrogenase | - |
Haemophilus influenzae |
aspartate-beta-semialdehyde dehydrogenase | - |
Vibrio cholerae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Escherichia coli | |
NADP+ | - |
Streptococcus pneumoniae | |
NADP+ | - |
Candida albicans | |
NADP+ | - |
Methanocaldococcus jannaschii | |
NADP+ | - |
Haemophilus influenzae | |
NADP+ | - |
Vibrio cholerae | |
NADPH | - |
Escherichia coli | |
NADPH | - |
Streptococcus pneumoniae | |
NADPH | - |
Candida albicans | |
NADPH | - |
Methanocaldococcus jannaschii | |
NADPH | - |
Haemophilus influenzae | |
NADPH | - |
Vibrio cholerae |
General Information | Comment | Organism |
---|---|---|
metabolism | aspartate beta-semialdehyde dehydrogenase is a key enzyme in an essential amino acid biosynthetic pathway catalyzing the second reaction in the aspartate pathway | Escherichia coli |
metabolism | aspartate beta-semialdehyde dehydrogenase is a key enzyme in an essential amino acid biosynthetic pathway catalyzing the second reaction in the aspartate pathway | Streptococcus pneumoniae |
metabolism | aspartate beta-semialdehyde dehydrogenase is a key enzyme in an essential amino acid biosynthetic pathway catalyzing the second reaction in the aspartate pathway | Candida albicans |
metabolism | aspartate beta-semialdehyde dehydrogenase is a key enzyme in an essential amino acid biosynthetic pathway catalyzing the second reaction in the aspartate pathway | Methanocaldococcus jannaschii |
metabolism | aspartate beta-semialdehyde dehydrogenase is a key enzyme in an essential amino acid biosynthetic pathway catalyzing the second reaction in the aspartate pathway | Haemophilus influenzae |
metabolism | aspartate beta-semialdehyde dehydrogenase is a key enzyme in an essential amino acid biosynthetic pathway catalyzing the second reaction in the aspartate pathway | Vibrio cholerae |