Literature summary for 1.2.1.11 extracted from

Viola, R.E.; Faehnle, C.R.; Blanco, J.; Moore, R.A.; Liu, X.; Arachea, B.T.; Pavlovsky, A.G.
The catalytic machinery of a key enzyme in amino acid biosynthesis (2011), J. Amino Acids, 2011, 352538.

Search for more literature for 1.2.1.11

Protein Variants

Protein Variants	Comment	Organism
C136S	the mutation virtually eliminates catalysis	Haemophilus influenzae
E243D	the mutant shows 1.2% activity compared to the wild type enzyme	Haemophilus influenzae
H277N	the mutant shows 1% activity compared to the wild type enzyme	Haemophilus influenzae
K246R	the mutant shows 3.3% activity compared to the wild type enzyme	Haemophilus influenzae
R103K	the mutant shows 0.4% activity compared to the wild type enzyme	Haemophilus influenzae
R103L	the mutant shows 0.07% activity compared to the wild type enzyme	Haemophilus influenzae
R267L	the mutant shows 9.5% activity compared to the wild type enzyme	Haemophilus influenzae
R270K	the mutant shows 0.1% activity compared to the wild type enzyme	Haemophilus influenzae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-4-aspartyl phosphate + NADPH + H+	Escherichia coli	-	L-aspartate 4-semialdehyde + phosphate + NADP+	-	r
L-4-aspartyl phosphate + NADPH + H+	Streptococcus pneumoniae	-	L-aspartate 4-semialdehyde + phosphate + NADP+	-	r
L-4-aspartyl phosphate + NADPH + H+	Candida albicans	-	L-aspartate 4-semialdehyde + phosphate + NADP+	-	r
L-4-aspartyl phosphate + NADPH + H+	Methanocaldococcus jannaschii	-	L-aspartate 4-semialdehyde + phosphate + NADP+	-	r
L-4-aspartyl phosphate + NADPH + H+	Haemophilus influenzae	-	L-aspartate 4-semialdehyde + phosphate + NADP+	-	r
L-4-aspartyl phosphate + NADPH + H+	Vibrio cholerae	-	L-aspartate 4-semialdehyde + phosphate + NADP+	-	r

Organism

Organism	UniProt	Comment	Textmining
Candida albicans	-	-	-
Escherichia coli	-	-	-
Haemophilus influenzae	P44801	-	-
Methanocaldococcus jannaschii	-	-	-
Streptococcus pneumoniae	-	-	-
Vibrio cholerae	Q9KQG2	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-4-aspartyl phosphate + NADPH + H+	-	Escherichia coli	L-aspartate 4-semialdehyde + phosphate + NADP+	-	r
L-4-aspartyl phosphate + NADPH + H+	-	Streptococcus pneumoniae	L-aspartate 4-semialdehyde + phosphate + NADP+	-	r
L-4-aspartyl phosphate + NADPH + H+	-	Candida albicans	L-aspartate 4-semialdehyde + phosphate + NADP+	-	r
L-4-aspartyl phosphate + NADPH + H+	-	Methanocaldococcus jannaschii	L-aspartate 4-semialdehyde + phosphate + NADP+	-	r
L-4-aspartyl phosphate + NADPH + H+	-	Haemophilus influenzae	L-aspartate 4-semialdehyde + phosphate + NADP+	-	r
L-4-aspartyl phosphate + NADPH + H+	-	Vibrio cholerae	L-aspartate 4-semialdehyde + phosphate + NADP+	-	r
L-aspartate 4-semialdehyde + phosphate + NADP+	-	Escherichia coli	L-4-aspartyl phosphate + NADPH + H+	-	r
L-aspartate 4-semialdehyde + phosphate + NADP+	-	Streptococcus pneumoniae	L-4-aspartyl phosphate + NADPH + H+	-	r
L-aspartate 4-semialdehyde + phosphate + NADP+	-	Candida albicans	L-4-aspartyl phosphate + NADPH + H+	-	r
L-aspartate 4-semialdehyde + phosphate + NADP+	-	Methanocaldococcus jannaschii	L-4-aspartyl phosphate + NADPH + H+	-	r
L-aspartate 4-semialdehyde + phosphate + NADP+	-	Haemophilus influenzae	L-4-aspartyl phosphate + NADPH + H+	-	r
L-aspartate 4-semialdehyde + phosphate + NADP+	-	Vibrio cholerae	L-4-aspartyl phosphate + NADPH + H+	-	r

Subunits

Subunits	Comment	Organism
homodimer	-	Escherichia coli
homodimer	-	Streptococcus pneumoniae
homodimer	-	Candida albicans
homodimer	-	Methanocaldococcus jannaschii
homodimer	-	Haemophilus influenzae
homodimer	-	Vibrio cholerae

Synonyms

Synonyms	Comment	Organism
ASADH	-	Escherichia coli
ASADH	-	Streptococcus pneumoniae
ASADH	-	Candida albicans
ASADH	-	Methanocaldococcus jannaschii
ASADH	-	Haemophilus influenzae
ASADH	-	Vibrio cholerae
aspartate-beta-semialdehyde dehydrogenase	-	Escherichia coli
aspartate-beta-semialdehyde dehydrogenase	-	Streptococcus pneumoniae
aspartate-beta-semialdehyde dehydrogenase	-	Candida albicans
aspartate-beta-semialdehyde dehydrogenase	-	Methanocaldococcus jannaschii
aspartate-beta-semialdehyde dehydrogenase	-	Haemophilus influenzae
aspartate-beta-semialdehyde dehydrogenase	-	Vibrio cholerae

Cofactor

Cofactor	Comment	Organism	Structure
NADP+	-	Escherichia coli
NADP+	-	Streptococcus pneumoniae
NADP+	-	Candida albicans
NADP+	-	Methanocaldococcus jannaschii
NADP+	-	Haemophilus influenzae
NADP+	-	Vibrio cholerae
NADPH	-	Escherichia coli
NADPH	-	Streptococcus pneumoniae
NADPH	-	Candida albicans
NADPH	-	Methanocaldococcus jannaschii
NADPH	-	Haemophilus influenzae
NADPH	-	Vibrio cholerae

General Information

General Information	Comment	Organism
metabolism	aspartate beta-semialdehyde dehydrogenase is a key enzyme in an essential amino acid biosynthetic pathway catalyzing the second reaction in the aspartate pathway	Escherichia coli
metabolism	aspartate beta-semialdehyde dehydrogenase is a key enzyme in an essential amino acid biosynthetic pathway catalyzing the second reaction in the aspartate pathway	Streptococcus pneumoniae
metabolism	aspartate beta-semialdehyde dehydrogenase is a key enzyme in an essential amino acid biosynthetic pathway catalyzing the second reaction in the aspartate pathway	Candida albicans
metabolism	aspartate beta-semialdehyde dehydrogenase is a key enzyme in an essential amino acid biosynthetic pathway catalyzing the second reaction in the aspartate pathway	Methanocaldococcus jannaschii
metabolism	aspartate beta-semialdehyde dehydrogenase is a key enzyme in an essential amino acid biosynthetic pathway catalyzing the second reaction in the aspartate pathway	Haemophilus influenzae
metabolism	aspartate beta-semialdehyde dehydrogenase is a key enzyme in an essential amino acid biosynthetic pathway catalyzing the second reaction in the aspartate pathway	Vibrio cholerae

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Release 2023.1 (January 2023)