Application | Comment | Organism |
---|---|---|
medicine | altered in the post-mortem substantia nigra samples from patients suffering from Parkinson's disease, decreased activity in the brain of Alzheimer's disease patients, involving regions affected by the disease as well as regions that remain normal, reduced activity or increased vulnerability to oxidative stress in fibroblasts from patients with presenlilin-1 mutation | Homo sapiens |
medicine | plays a role in neurodegenerative diseases | Rattus norvegicus |
additional information | in post-mortem mice brain samples the activity is quickly lost, whereas the activity of another TPP-dependent enzyme, PDH, remains unalterd for at least 24 h | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | heterozygous knockout mice deficient in the E3 subunit produce significantly less H2O2 than mitochondria form their littermate wild-type mice | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
reactive oxygen species | alpha-KGDH can generate reactive oxygen species during its catalytic function, which is regulated by the NADH/NAD+ ratio, formation by alpha-KGDH is attributed to the E3 subunit | Mus musculus | |
reactive oxygen species | aconitase in the Krebs cycle is more vulnerable than alpha-KGDH to reactive oxygen species, alpha-KGDH can generate reactive oxygen species during its catalytic function, which is regulated by the NADH/NAD+ ratio, as long as alpha-KGDH is functional NADH generation in the Krebs cycle is maintained | Rattus norvegicus | |
Zn2+ | may play a role in the inhibition of alpha-KGDH during ischemia or reperfusion, is present in elavated concentrations in such cells | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Mus musculus | 5739 | - |
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Sus scrofa | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brain | - |
Homo sapiens | - |
forebrain | - |
Rattus norvegicus | - |
heart | - |
Sus scrofa | - |
neuron | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine | - |
Rattus norvegicus | [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
alpha-ketoglutarate dehydrogenase | - |
Mus musculus |
alpha-ketoglutarate dehydrogenase | - |
Homo sapiens |
alpha-ketoglutarate dehydrogenase | - |
Rattus norvegicus |
alpha-ketoglutarate dehydrogenase | - |
Sus scrofa |
alpha-KGDH | - |
Mus musculus |
alpha-KGDH | - |
Homo sapiens |
alpha-KGDH | - |
Rattus norvegicus |
alpha-KGDH | - |
Sus scrofa |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.6 | 7.4 | - |
Sus scrofa |
7.2 | 7.4 | - |
Mus musculus |