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Literature summary for 1.2.1.104 extracted from

  • Ohbayashi, I.; Huang, S.; Fukaki, H.; Song, X.; Sun, S.; Morita, M.T.; Tasaka, M.; Millar, A.H.; Furutani, M.
    Mitochondrial pyruvate dehydrogenase contributes to auxin-regulated organ development (2019), Plant Physiol., 180, 896-909 .
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Arabidopsis thaliana 5739
-

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q8H1Y0 and Q38799 Q8H1Y0 i.e. IAR4, E1 component subunit alpha-2, Q38799 i.e. PDH2, E1 component subunit beta-1, cf. EC 1.2.4.1
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Synonyms

Synonyms Comment Organism
IAR4 cf. EC 1.2.4.1 Arabidopsis thaliana
MAB1
-
 Arabidopsis thaliana
PH2
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
physiological function mitochondrial PDC E1 contributes to polar auxin transport during organ development. MAB1 encodes a mitochondrial PDC E1beta subunit that can form both a homodimer and a heterodimer with alpha-subunit IAR4. The MAB1 mutation impairs MAB1 homodimerization, reduces the abundance of IAR4 and IAR4L, weakens PDC enzymatic activity, and diminishes mitochondrial respiration. Mutation leads to significant changes in metabolites including amino acids, and an accumulation of Ala. In MAB1 mutants and seedlings where the TCA cycle is pharmacologically blocked, reduced abundance of the PIN-FORMED (PIN) auxin efflux carriers is found Arabidopsis thaliana