General Stability | Organism |
---|---|
PDC displays size versatility in an ionic strength-dependent manner. PDC (yPDC) is a salt-labile complex that dissociates into sub-megadalton individual components even under physiological ionic strength. Each oligomeric component of PDC displays a larger size than expected. The activity of PDC is reduced in higher ionic strength | Saccharomyces cerevisiae |
PDC displays size versatility in an ionic strength-dependent manner. PDC (yPDC) is a salt-labile complex that dissociates into sub-megadalton individual components even under physiological ionic strength. Each oligomeric component of PDC displays a larger size than expected. The activity of PDC is reduced in higher ionic strength | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Saccharomyces cerevisiae | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
230000 | - |
gel filtration, mammalian E1p, mE1palpha (PDHA1) and mE1pbeta (PDHB1), and mE3 components are detected mostly in sub-megadalton size fractions of the high ionic strength fraction | Homo sapiens |
230000 | 440000 | gel filtration, enzyme isolated from nuclei-enriched low sedimentation rate fraction | Saccharomyces cerevisiae |
1000000 | - |
and 2000000, gel filtration, enzyme isolated from mitochondria-enriched high sedimentation rate fraction | Saccharomyces cerevisiae |
2000000 | - |
and 1000000, gel filtration, enzyme isolated from mitochondria-enriched high sedimentation rate fraction | Saccharomyces cerevisiae |
2000000 | - |
gel filtration, E2 component eluted only as a megadalton complex even in the high sedimentation rate fraction | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P08559 and P11177 and O00330 and P10515 and P09622 | P08559 i.e. subunit PdhA1, cf. EC 1.2.4.1, P11177 i.e. subunit PdhB1, cf. EC 1.2.4.1, O00330 i.e. subunit PdhX, P10515 i.e. subunit DlaT, cf. EC 2.3.1.12, P09622 i.e. subunit Dld, cf. EC 1.8.1.4, respectively | - |
Saccharomyces cerevisiae | - |
- |
- |
Saccharomyces cerevisiae | P16387 | E1 component subunit alpha | - |
Saccharomyces cerevisiae BY4741 | - |
- |
- |
Saccharomyces cerevisiae BY4741 | P16387 | E1 component subunit alpha | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293T cell | - |
Homo sapiens | - |
Subunits | Comment | Organism |
---|---|---|
More | PDC displays size versatility in an ionic strength-dependent manner. PDC is a salt-labile complex that dissociates into sub-megadalton individual components even under physiological ionic strength. Each oligomeric component of PDC displays a larger size than expected. The activity of PDC is reduced in higher ionic strength | Saccharomyces cerevisiae |
More | PDC displays size versatility in an ionic strength-dependent manner. PDC is a salt-labile complex that dissociates into sub-megadalton individual components even under physiological ionic strength. Each oligomeric component of PDC displays a larger size than expected. The activity of PDC is reduced in higher ionic strength | Homo sapiens |
More | the pyruvate dehydrogenase complex PDC displays size versatility in an ionic strength-dependent manner. Yeast PDC is a salt-labile complex that dissociates into submegadalton individual components even under physiological ionic strength. The ionic strength can modulate its catalytic activity. E1 elutes at fractions for about 440 kDa proteins that mainly contain E1alpha, E1beta, and a nominal amount of E2. E3 elutes at fractions for about 230 kDa, which contain mostly E3 | Saccharomyces cerevisiae |
Synonyms | Comment | Organism |
---|---|---|
Pda1 | cf. EC 1.2.4.1 | Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
physiological function | the pyruvate dehydrogenase complex PDC displays size versatility in an ionic strength-dependent manner. Yeast PDC is a salt-labile complex that dissociates into submegadalton individual components even under physiological ionic strength. The ionic strength can modulate its catalytic activity | Saccharomyces cerevisiae |