Literature summary for 1.2.1.104 extracted from

Gey, U.; Czupalla, C.; Hoflack, B.; Roedel, G.; Krause-Buchholz, U.
Yeast pyruvate dehydrogenase complex is regulated by a concerted activity of two kinases and two phosphatases (2008), J. Biol. Chem., 283, 9759-9767 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Saccharomyces cerevisiae	5739	-

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	P16387	Pda1, i.e. E1 component subunit alpha, cf. EC 1.2.4.1	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	mitochondrial proteins, Pkp2 (Ygl059wp) and Ppp2 (Ycr079wp), are engaged in the regulation of the pyruvate dehydrogenase complex by affecting the phosphorylation state of subunit Pda1	Saccharomyces cerevisiae

Synonyms

Synonyms	Comment	Organism
Pda1	-	Saccharomyces cerevisiae

General Information

General Information	Comment	Organism
physiological function	mitochondrial proteins, Pkp2 (Ygl059wp) and Ppp2 (Ycr079wp), are engaged in the regulation of the pyruvate dehydrogenase complex by affecting the phosphorylation state of subunit Pda1. Ppp2 is almost exclusively localized in the mitochondrial matrix and associated with the complex. Cells lacking Ppp2 but also cells with a non-functional pyruvate dehydrogenase complex due to deletion of Pda1 possess similar sensitivity toward rapamycin	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)