Literature summary for 1.2.1.104 extracted from

Wang, X.; Wang, A.; Zhu, L.; Hua, D.; Qin, J.
Altering the sensitivity of Escherichia coli pyruvate dehydrogenase complex to NADH inhibition by structure-guided design (2018), Enzyme Microb. Technol., 119, 52-57 .

Search for more literature for 1.2.1.104

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Escherichia coli

Protein Variants

Protein Variants	Comment	Organism
I350V/A351V/A358V	PDH activity with the triple mutant at an [NADH]/[NAD+] ratio of 0.15 is higher than that of the wild-type without NADH addition. Within the PDH complex, the mutant is also less sensitive to inhibition by NADH	Escherichia coli

Inhibitors

Inhibitors	Comment	Organism	Structure
NADH	-	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P0A9P0	E3 component LpdA, cf. EC 1.8.1.4	-

Synonyms

Synonyms	Comment	Organism
LpdA	-	Escherichia coli

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Release 2023.1 (January 2023)