Literature summary for 1.2.1.104 extracted from

Cripps, R.E.; Eley, K.; Leak, D.J.; Rudd, B.; Taylor, M.; Todd, M.; Boakes, S.; Martin, S.; Atkinson, T.
Metabolic engineering of Geobacillus thermoglucosidasius for high yield ethanol production (2009), Metab. Eng., 11, 398-408.

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Application

Application	Comment	Organism
synthesis	metabolic engineering of Geobacillus thermoglucosidasius to divert the fermentative carbon flux from a mixed acid pathway to one in which ethanol becomes the major product, involving elimination of the lactate dehydrogenase and pyruvate formate lyase pathways by disruption of the ldh and pflB genes, respectively, and upregulation of expression of pyruvate dehydrogenase. Pyruvate dehydrogenase is active under anaerobic conditions, but expressed suboptimally for a role as the primary fermentation pathway. Strains with all three modifications form ethanol efficiently and rapidly at temperatures in excess of 60°C in yields in excess of 90% of theoretical. The strains also efficiently ferment cellobiose and a mixed hexose and pentose feed	Parageobacillus thermoglucosidasius

Cloned(Commentary)

Cloned (Comment)	Organism
-	Parageobacillus thermoglucosidasius

Organism

Organism	UniProt	Comment	Textmining
Parageobacillus thermoglucosidasius	-	-	-
Parageobacillus thermoglucosidasius NCIMB 11955	-	-	-

Synonyms

Synonyms	Comment	Organism
PDHa	-	Parageobacillus thermoglucosidasius

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Release 2023.1 (January 2023)