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Literature summary for 1.2.1.104 extracted from

  • Xing, G.; Ren, M.; Watson, W.A.; O’Neill, J.T.; Verma, A.
    Traumatic brain injury-induced expression and phosphorylation of pyruvate dehydrogenase: a mechanism of dysregulated glucose metabolism (2009), Neurosci. Lett., 454, 38-42.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pyruvate + CoA + NAD+ Rattus norvegicus
-
 acetyl-CoA + CO2 + NADH
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein PDH activity is inhibited by the phosphorylation of its E1alpha1 subunit Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyruvate + CoA + NAD+
-
 Rattus norvegicus acetyl-CoA + CO2 + NADH
-
 ?

Synonyms

Synonyms Comment Organism
PDH
-
 Rattus norvegicus
PDHE1alpha1 subunit Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Rattus norvegicus
thiamine diphosphate
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus PDHE1alpha1 protein and phosphorylation level decrease significantly ipsilateral to controlled cortical impact and contralateral to controlled cortical impact at 4 h, 24 h, 3- and 7-day post-controlled cortical impact, respectively down
Rattus norvegicus there is a moderate increase of PDHE1alpha1 mRNA in ipsilateral CCI and contralateral controlled cortical impact (1.2-1.6fold) at 4 h and 24 h post-controlled cortical impact. PDHE1alpha1 mRNA increases moderately (1.4fold) in the craniotomy group at 4 h, 24 h and 7-day post-surgery up

General Information

General Information Comment Organism
physiological function pyruvate dehydrogenase is the rate-limiting enzyme coupling cytosolic glycolysis to mitochondrial citric acid cycle, and plays a critical role in maintaining homeostasis of brain glucose metabolism Rattus norvegicus